FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566362183> ?p ?o ?g. }

• W1566362183 endingPage "16095" @default.
• W1566362183 startingPage "16087" @default.
• W1566362183 abstract "Chick hepatocytes in primary culture have been used to study the homologous and heterologous pathways of glucagon-induced desensitization of adenylyl cyclase. Scatchard analysis and guanine nucleotide effects on dissociation kinetics indicate that the initial phase of homologous desensitization, an increase in low affinity glucagon receptors due to the rapid uncoupling of the receptor from Gs, is essentially complete within 5 min. These receptors recouple within 20 min upon removal of glucagon. Upon prolonged (2 h or more) exposure of hepatocytes to glucagon, disappearance of low affinity receptors from cell surface membranes constitutes the second phase of homologous desensitization. Recovery of these lost and presumably internalized receptors requires more than 12 h following the removal of glucagon but is not dependent on new protein synthesis. The heterologous phase of desensitization is slower, requiring 20-30 min of glucagon treatment to reach completion. Stimulation of adenylyl cyclase by hormonal and nonhormonal effectors is similarly reduced, indicating a common defect in this desensitized state. Agonist occupancy of other hormone receptors coupled to adenylyl cyclase in hepatocytes, such as beta-adrenergic, prostaglandin E1, and vasoactive intestinal peptide, results in heterologous desensitization. Heterologous desensitization is rapidly reversed (within 30 min) upon partial removal of glucagon, under conditions allowing the maintenance of the homologously desensitized state. Neither onset of nor recovery from heterologous desensitization requires protein synthesis. These data indicate that homologous and heterologous desensitization occurs by independent mechanisms. Homologous desensitization involves uncoupling of the glucagon receptor from Gs, followed by removal of these uncoupled receptors from the cell surface. Heterologous desensitization represents a second level of cellular control of hormonal responsiveness to be turned on when the cell is subjected to prolonged hormonal stimulation and withdrawn when hormone levels are lowered." @default.
• W1566362183 created "2016-06-24" @default.
• W1566362183 creator A5022772284 @default.
• W1566362183 creator A5065778793 @default.
• W1566362183 date "1988-11-01" @default.
• W1566362183 modified "2023-10-15" @default.
• W1566362183 title "Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. Evidence for multiple pathways." @default.
• W1566362183 cites W1484637220 @default.
• W1566362183 cites W1488128956 @default.
• W1566362183 cites W1494849067 @default.
• W1566362183 cites W1499316111 @default.
• W1566362183 cites W1515731319 @default.
• W1566362183 cites W1552908089 @default.
• W1566362183 cites W1562393866 @default.
• W1566362183 cites W1586267394 @default.
• W1566362183 cites W1775749144 @default.
• W1566362183 cites W1972928024 @default.
• W1566362183 cites W1974998523 @default.
• W1566362183 cites W1977676788 @default.
• W1566362183 cites W1983649348 @default.
• W1566362183 cites W1996702116 @default.
• W1566362183 cites W1998388006 @default.
• W1566362183 cites W2001578819 @default.
• W1566362183 cites W2017262732 @default.
• W1566362183 cites W2023627293 @default.
• W1566362183 cites W2023874479 @default.
• W1566362183 cites W2023948432 @default.
• W1566362183 cites W2025930377 @default.
• W1566362183 cites W2033347336 @default.
• W1566362183 cites W2042442620 @default.
• W1566362183 cites W2046783603 @default.
• W1566362183 cites W2056374369 @default.
• W1566362183 cites W2058004531 @default.
• W1566362183 cites W2060233342 @default.
• W1566362183 cites W2069474956 @default.
• W1566362183 cites W2083990639 @default.
• W1566362183 cites W2100837269 @default.
• W1566362183 cites W2132702380 @default.
• W1566362183 cites W2163964444 @default.
• W1566362183 cites W2164226796 @default.
• W1566362183 cites W2169503005 @default.
• W1566362183 cites W2177387315 @default.
• W1566362183 cites W2342123394 @default.
• W1566362183 cites W2345438193 @default.
• W1566362183 cites W3220325 @default.
• W1566362183 doi "https://doi.org/10.1016/s0021-9258(18)37562-8" @default.
• W1566362183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2846535" @default.
• W1566362183 hasPublicationYear "1988" @default.
• W1566362183 type Work @default.
• W1566362183 sameAs 1566362183 @default.
• W1566362183 citedByCount "26" @default.
• W1566362183 countsByYear W15663621832015 @default.
• W1566362183 crossrefType "journal-article" @default.
• W1566362183 hasAuthorship W1566362183A5022772284 @default.
• W1566362183 hasAuthorship W1566362183A5065778793 @default.
• W1566362183 hasBestOaLocation W15663621831 @default.
• W1566362183 hasConcept C117794106 @default.
• W1566362183 hasConcept C121332964 @default.
• W1566362183 hasConcept C126322002 @default.
• W1566362183 hasConcept C1276947 @default.
• W1566362183 hasConcept C134018914 @default.
• W1566362183 hasConcept C170493617 @default.
• W1566362183 hasConcept C181199279 @default.
• W1566362183 hasConcept C185592680 @default.
• W1566362183 hasConcept C2751546 @default.
• W1566362183 hasConcept C2777977315 @default.
• W1566362183 hasConcept C2778563252 @default.
• W1566362183 hasConcept C2779178603 @default.
• W1566362183 hasConcept C2779779143 @default.
• W1566362183 hasConcept C2780069284 @default.
• W1566362183 hasConcept C55493867 @default.
• W1566362183 hasConcept C62478195 @default.
• W1566362183 hasConcept C69101867 @default.
• W1566362183 hasConcept C71315377 @default.
• W1566362183 hasConcept C71924100 @default.
• W1566362183 hasConcept C86803240 @default.
• W1566362183 hasConcept C95444343 @default.
• W1566362183 hasConceptScore W1566362183C117794106 @default.
• W1566362183 hasConceptScore W1566362183C121332964 @default.
• W1566362183 hasConceptScore W1566362183C126322002 @default.
• W1566362183 hasConceptScore W1566362183C1276947 @default.
• W1566362183 hasConceptScore W1566362183C134018914 @default.
• W1566362183 hasConceptScore W1566362183C170493617 @default.
• W1566362183 hasConceptScore W1566362183C181199279 @default.
• W1566362183 hasConceptScore W1566362183C185592680 @default.
• W1566362183 hasConceptScore W1566362183C2751546 @default.
• W1566362183 hasConceptScore W1566362183C2777977315 @default.
• W1566362183 hasConceptScore W1566362183C2778563252 @default.
• W1566362183 hasConceptScore W1566362183C2779178603 @default.
• W1566362183 hasConceptScore W1566362183C2779779143 @default.
• W1566362183 hasConceptScore W1566362183C2780069284 @default.
• W1566362183 hasConceptScore W1566362183C55493867 @default.
• W1566362183 hasConceptScore W1566362183C62478195 @default.
• W1566362183 hasConceptScore W1566362183C69101867 @default.
• W1566362183 hasConceptScore W1566362183C71315377 @default.
• W1566362183 hasConceptScore W1566362183C71924100 @default.
• W1566362183 hasConceptScore W1566362183C86803240 @default.
• W1566362183 hasConceptScore W1566362183C95444343 @default.

• next