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• W1566378475 abstract "Prostate cancer is one of the most common malignancies in Western countries and the world (Baade et al., 2009). It is the third most common cause of death from cancer in men of all ages and the most common cause of death from cancer in men over age 75. The current standard therapies for prostate cancer include radiation, surgery, hormonal therapy and chemotherapy (Debruyne, 2002; Freytag et al., 2007; Nelius et al., 2009; Rozkova et al., 2009). Chemotherapy is almost always a salvage therapy for advanced prostate cancer, and chemoresistance is emerging problem in prostate cancer therapy. Strategies to overcome the chemoresistance of prostate cancer cells have not been developed partially because mechanisms of it are unknown and likely to be numerous. Chemoresistance has a tendency to occur both to clinically established therapeutic agents and novel targeted therapeutics implicating both intrinsic and acquired mechanisms of drug resistance (Djeu & Wei, 2009). Most likely, these are the mechanisms which are universal for cytoprotection from cell death induced by various factors. Cell death by apoptosis is one of the most universal mechanisms of cell response to injury. It plays the major role in carcinogenesis and prostate tumor progression. Suppression of apoptosis was proposed to cause inappropriate survival of genetically aberrant cells during carcinogenesis (Vineis, 2003). Cancer cells seem to be designed to propagate and survive in a new and hostile environment by suppressing their natural mechanisms of cell death. The neoplastic transformation of prostate epithelial cells is known to be associated with decreased apoptotic cell death (Inokuchi et al., 2009; Shilkaitis et al., 2000). The progression of prostate cancer, in particular, androgen-independent prostate cancer or prostate adenocarcinomas, was also shown to be associated with decreased apoptosis (Raffo et al., 1995; Singh & Lokeshwar, 2009). The latter is the predominant form of tumor cell demise caused by chemotherapeutic agents and it plays an important role in cancer chemosensitivity and radiosensitivity (Arnold & Isaacs, 2002; Debes & Tindall, 2004). Targeting various mechanisms of apoptosis to cure prostate cancer has been suggested in many studies, naming potential molecular targets and key apoptotic regulators such as upstream and downstream caspases, p53, Phosphatase and tensin homolog (PTEN), prostate apoptosis response gene-4 (Par-4), Bcl-2 (B-cell lymphoma 2) protein, transcription factor" @default.
• W1566378475 created "2016-06-24" @default.
• W1566378475 creator A5029363724 @default.
• W1566378475 creator A5081015625 @default.
• W1566378475 creator A5091811978 @default.
• W1566378475 date "2011-11-25" @default.
• W1566378475 modified "2023-10-16" @default.
• W1566378475 title "Cytotoxic Endonucleases: New Targets for Prostate Cancer Chemotherapy" @default.
• W1566378475 cites W134308212 @default.
• W1566378475 cites W1480948328 @default.
• W1566378475 cites W1482074366 @default.
• W1566378475 cites W1532302462 @default.
• W1566378475 cites W1536961425 @default.
• W1566378475 cites W1538805645 @default.
• W1566378475 cites W1553172257 @default.
• W1566378475 cites W1567114372 @default.
• W1566378475 cites W1593148603 @default.
• W1566378475 cites W1601185840 @default.
• W1566378475 cites W1602673445 @default.
• W1566378475 cites W1614924811 @default.
• W1566378475 cites W1752198036 @default.
• W1566378475 cites W1845459216 @default.
• W1566378475 cites W1854925881 @default.
• W1566378475 cites W1870957800 @default.
• W1566378475 cites W1965551263 @default.
• W1566378475 cites W1971183831 @default.
• W1566378475 cites W1972377673 @default.
• W1566378475 cites W1977422169 @default.
• W1566378475 cites W1980462656 @default.
• W1566378475 cites W1983131542 @default.
• W1566378475 cites W1984887828 @default.
• W1566378475 cites W1986866765 @default.
• W1566378475 cites W1987941313 @default.
• W1566378475 cites W1991446103 @default.
• W1566378475 cites W1992672104 @default.
• W1566378475 cites W1993955706 @default.
• W1566378475 cites W1994839373 @default.
• W1566378475 cites W1996857140 @default.
• W1566378475 cites W1997960190 @default.
• W1566378475 cites W2004172747 @default.
• W1566378475 cites W2004242127 @default.
• W1566378475 cites W2006826612 @default.
• W1566378475 cites W2007510875 @default.
• W1566378475 cites W2009121506 @default.
• W1566378475 cites W2009458315 @default.
• W1566378475 cites W2010557665 @default.
• W1566378475 cites W2012948694 @default.
• W1566378475 cites W2025212496 @default.
• W1566378475 cites W2030285932 @default.
• W1566378475 cites W2033376776 @default.
• W1566378475 cites W2034678057 @default.
• W1566378475 cites W2039656014 @default.
• W1566378475 cites W2040149948 @default.
• W1566378475 cites W2040285119 @default.
• W1566378475 cites W2041089729 @default.
• W1566378475 cites W2047727890 @default.
• W1566378475 cites W2049033330 @default.
• W1566378475 cites W2049651307 @default.
• W1566378475 cites W2049711380 @default.
• W1566378475 cites W2051190539 @default.
• W1566378475 cites W2056489198 @default.
• W1566378475 cites W2060348125 @default.
• W1566378475 cites W2060390343 @default.
• W1566378475 cites W2061379238 @default.
• W1566378475 cites W2062214836 @default.
• W1566378475 cites W2064115427 @default.
• W1566378475 cites W2066086539 @default.
• W1566378475 cites W2068039441 @default.
• W1566378475 cites W2074879449 @default.
• W1566378475 cites W2081197593 @default.
• W1566378475 cites W2081293878 @default.
• W1566378475 cites W2084398875 @default.
• W1566378475 cites W2107136826 @default.
• W1566378475 cites W2108179736 @default.
• W1566378475 cites W2108494968 @default.
• W1566378475 cites W2111584908 @default.
• W1566378475 cites W2117552593 @default.
• W1566378475 cites W2122911345 @default.
• W1566378475 cites W2125483893 @default.
• W1566378475 cites W2126689461 @default.
• W1566378475 cites W2128717686 @default.
• W1566378475 cites W2132508967 @default.
• W1566378475 cites W2133478283 @default.
• W1566378475 cites W2133918562 @default.
• W1566378475 cites W2137302120 @default.
• W1566378475 cites W2146745114 @default.
• W1566378475 cites W2155839539 @default.
• W1566378475 cites W2159500972 @default.
• W1566378475 cites W2162957160 @default.
• W1566378475 cites W2163581092 @default.
• W1566378475 cites W2315023249 @default.
• W1566378475 cites W2401755783 @default.
• W1566378475 cites W2416868771 @default.
• W1566378475 cites W2416945424 @default.
• W1566378475 cites W2465831218 @default.
• W1566378475 cites W58950010 @default.
• W1566378475 doi "https://doi.org/10.5772/25585" @default.
• W1566378475 hasPublicationYear "2011" @default.
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