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• W1566382820 startingPage "4547" @default.
• W1566382820 abstract "Stress responses play an important role in shaping species distributions and robustness to climate change. We investigated how stress responses alter the contribution of additive genetic variation to gene expression during development of the purple sea urchin, Strongylocentrotus purpuratus, under increased temperatures that model realistic climate change scenarios. We first measured gene expression responses in the embryos by RNA-seq to characterize molecular signatures of mild, chronic temperature stress in an unbiased manner. We found that an increase from 12 to 18 °C caused widespread alterations in gene expression including in genes involved in protein folding, RNA processing and development. To understand the quantitative genetic architecture of this response, we then focused on a well-characterized gene network involved in endomesoderm and ectoderm specification. Using a breeding design with wild-caught individuals, we measured genetic and gene-environment interaction effects on 72 genes within this network. We found genetic or maternal effects in 33 of these genes and that the genetic effects were correlated in the network. Fourteen network genes also responded to higher temperatures, but we found no significant genotype-environment interactions in any of the genes. This absence may be owing to an effective buffering of the temperature perturbations within the network. In support of this hypothesis, perturbations to regulatory genes did not affect the expression of the genes that they regulate. Together, these results provide novel insights into the relationship between environmental change and developmental evolution and suggest that climate change may not expose large amounts of cryptic genetic variation to selection in this species." @default.
• W1566382820 created "2016-06-24" @default.
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• W1566382820 date "2012-08-01" @default.
• W1566382820 modified "2023-10-02" @default.
• W1566382820 title "Genetics of gene expression responses to temperature stress in a sea urchin gene network" @default.
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• W1566382820 cites W1973285535 @default.
• W1566382820 cites W1975200549 @default.
• W1566382820 cites W1979624874 @default.
• W1566382820 cites W1982103833 @default.
• W1566382820 cites W1986515540 @default.
• W1566382820 cites W1993269979 @default.
• W1566382820 cites W1995760984 @default.
• W1566382820 cites W2001600242 @default.
• W1566382820 cites W2003164867 @default.
• W1566382820 cites W2008258279 @default.
• W1566382820 cites W2018365640 @default.
• W1566382820 cites W2019433333 @default.
• W1566382820 cites W2032074345 @default.
• W1566382820 cites W2044378614 @default.
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• W1566382820 cites W2045925483 @default.
• W1566382820 cites W2049485508 @default.
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• W1566382820 cites W2070102051 @default.
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• W1566382820 cites W2071270967 @default.
• W1566382820 cites W2072632935 @default.
• W1566382820 cites W2075809877 @default.
• W1566382820 cites W2076774126 @default.
• W1566382820 cites W2079319076 @default.
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• W1566382820 cites W2114104545 @default.
• W1566382820 cites W2120296627 @default.
• W1566382820 cites W2123111228 @default.
• W1566382820 cites W2123598330 @default.
• W1566382820 cites W2124985265 @default.
• W1566382820 cites W2125821068 @default.
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• W1566382820 doi "https://doi.org/10.1111/j.1365-294x.2012.05717.x" @default.
• W1566382820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3866972" @default.
• W1566382820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22856327" @default.
• W1566382820 hasPublicationYear "2012" @default.
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