FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566387143> ?p ?o ?g. }

• W1566387143 abstract "Several alternative treatments have recently been developed for metastatic renal cell carcinoma (RCC). Vascular endothelial growth factor (VEGF) is a potent pro-angiogenic protein, which is responsible for increased vasculature and tumor-growth in RCC. Fundamentally, a mutation in the von Hippel-Lindau (VHL) tumor suppressor gene induces overexpression of VEGF via accumulation of hypoxia-inducible factor (HIF)-1 in RCC. Several agents inhibiting the VEGF signaling cascade, such as sorafenib, sunitinib and bevacizumab, have been found to exert significant anti-tumor effects and provide meaningful clinical benefits. Furthermore, temsirolimus and everolimus, inhibitors of the mammalian target of rapamycin (mTOR), which block the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway involved in numerous cellular functions including cell proliferation, survival and angiogenesis, have been found to be effective agents against advanced RCC in the clinical setting. Although molecular targeting therapies against the VEGF or mTOR signaling pathway have revolutionized the treatment of advanced RCC, no curative therapy has yet been established." @default.
• W1566387143 created "2016-06-24" @default.
• W1566387143 creator A5000880725 @default.
• W1566387143 creator A5027578308 @default.
• W1566387143 date "2012-02-03" @default.
• W1566387143 modified "2023-09-26" @default.
• W1566387143 title "Anticancer Target Molecules Against the SCF Ubiquitin E3 Ligase in RCC: Potential Approaches to the NEDD8 Pathway" @default.
• W1566387143 cites W1491459594 @default.
• W1566387143 cites W1495670272 @default.
• W1566387143 cites W1864563621 @default.
• W1566387143 cites W1979350858 @default.
• W1566387143 cites W1986016012 @default.
• W1566387143 cites W1986068161 @default.
• W1566387143 cites W1988377666 @default.
• W1566387143 cites W2001177765 @default.
• W1566387143 cites W2001827754 @default.
• W1566387143 cites W2003062513 @default.
• W1566387143 cites W2010264424 @default.
• W1566387143 cites W2016627742 @default.
• W1566387143 cites W2045156375 @default.
• W1566387143 cites W2057152378 @default.
• W1566387143 cites W2062980622 @default.
• W1566387143 cites W2065711748 @default.
• W1566387143 cites W2066147619 @default.
• W1566387143 cites W2068230503 @default.
• W1566387143 cites W2071863797 @default.
• W1566387143 cites W2072337406 @default.
• W1566387143 cites W2076194625 @default.
• W1566387143 cites W2080939719 @default.
• W1566387143 cites W2090425574 @default.
• W1566387143 cites W2091124764 @default.
• W1566387143 cites W2094021381 @default.
• W1566387143 cites W2100547839 @default.
• W1566387143 cites W2131668748 @default.
• W1566387143 cites W2149678150 @default.
• W1566387143 cites W2155420844 @default.
• W1566387143 cites W2161469401 @default.
• W1566387143 cites W2161523490 @default.
• W1566387143 cites W2165468754 @default.
• W1566387143 cites W2166987747 @default.
• W1566387143 cites W2168979257 @default.
• W1566387143 cites W2345196156 @default.
• W1566387143 doi "https://doi.org/10.5772/26409" @default.
• W1566387143 hasPublicationYear "2012" @default.
• W1566387143 type Work @default.
• W1566387143 sameAs 1566387143 @default.
• W1566387143 citedByCount "0" @default.
• W1566387143 crossrefType "book-chapter" @default.
• W1566387143 hasAuthorship W1566387143A5000880725 @default.
• W1566387143 hasAuthorship W1566387143A5027578308 @default.
• W1566387143 hasBestOaLocation W15663871431 @default.
• W1566387143 hasConcept C104317684 @default.
• W1566387143 hasConcept C126322002 @default.
• W1566387143 hasConcept C134459356 @default.
• W1566387143 hasConcept C167734588 @default.
• W1566387143 hasConcept C183713625 @default.
• W1566387143 hasConcept C25602115 @default.
• W1566387143 hasConcept C2776694085 @default.
• W1566387143 hasConcept C2776820818 @default.
• W1566387143 hasConcept C2777025900 @default.
• W1566387143 hasConcept C2777472916 @default.
• W1566387143 hasConcept C2777802072 @default.
• W1566387143 hasConcept C2778019345 @default.
• W1566387143 hasConcept C2778439243 @default.
• W1566387143 hasConcept C2778695046 @default.
• W1566387143 hasConcept C2779490328 @default.
• W1566387143 hasConcept C2779699572 @default.
• W1566387143 hasConcept C2780394083 @default.
• W1566387143 hasConcept C502942594 @default.
• W1566387143 hasConcept C55493867 @default.
• W1566387143 hasConcept C62478195 @default.
• W1566387143 hasConcept C71924100 @default.
• W1566387143 hasConcept C75217442 @default.
• W1566387143 hasConcept C86554907 @default.
• W1566387143 hasConcept C86803240 @default.
• W1566387143 hasConcept C95444343 @default.
• W1566387143 hasConcept C98490376 @default.
• W1566387143 hasConceptScore W1566387143C104317684 @default.
• W1566387143 hasConceptScore W1566387143C126322002 @default.
• W1566387143 hasConceptScore W1566387143C134459356 @default.
• W1566387143 hasConceptScore W1566387143C167734588 @default.
• W1566387143 hasConceptScore W1566387143C183713625 @default.
• W1566387143 hasConceptScore W1566387143C25602115 @default.
• W1566387143 hasConceptScore W1566387143C2776694085 @default.
• W1566387143 hasConceptScore W1566387143C2776820818 @default.
• W1566387143 hasConceptScore W1566387143C2777025900 @default.
• W1566387143 hasConceptScore W1566387143C2777472916 @default.
• W1566387143 hasConceptScore W1566387143C2777802072 @default.
• W1566387143 hasConceptScore W1566387143C2778019345 @default.
• W1566387143 hasConceptScore W1566387143C2778439243 @default.
• W1566387143 hasConceptScore W1566387143C2778695046 @default.
• W1566387143 hasConceptScore W1566387143C2779490328 @default.
• W1566387143 hasConceptScore W1566387143C2779699572 @default.
• W1566387143 hasConceptScore W1566387143C2780394083 @default.
• W1566387143 hasConceptScore W1566387143C502942594 @default.
• W1566387143 hasConceptScore W1566387143C55493867 @default.
• W1566387143 hasConceptScore W1566387143C62478195 @default.
• W1566387143 hasConceptScore W1566387143C71924100 @default.
• W1566387143 hasConceptScore W1566387143C75217442 @default.
• W1566387143 hasConceptScore W1566387143C86554907 @default.

• next