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• W1566396845 abstract "Predominant immune cells in colorectal cancer (CRC) are CD4+ T-lymphocytes. The hypotheses are that (i) the CD4+ component in CRC is made up of different functional subtypes; T-helper and T-regulatory cells (TREG), (ii) CD4+ cells in CRC are heterogeneous in their expression of homing markers, and (iii) the presence of homing markers can identify cells with a typical functional response. Peripheral blood lymphocytes were obtained by ficoll separation from 38 patients, with matched tumour (TIL) and lymph node lymphocytes extracted using mechanical disaggregation from 35 and 26 patients respectively. The presence of CD4+CD25+ cells as a putative marker for TREG was assessed. CD4+ cells were stained with a panel of 18 homing markers to identify up-regulation in TIL from CRC. Based on homing markers identified, lymphocyte isolates were separated using Flow Assisted Cell Sorting or MACS separation, and the functional ability of these subpopulations assessed using ELISA. TIL from CRC display up-regulation of homing factors CXCR6, CCR5, and CCR6 (p=0.0001, 0.01782 and 0.5346 respectively). Stimulated CD4+CXCR6+TIL produced interferon-gamma,involved in anti-tumour responses. We have confirmed the presence of a population of inhibitory FoxP3+ and CD4+CD25+ TREG. The techniques validated could be used to monitor the effect of future vaccine trials." @default.
• W1566396845 created "2016-06-24" @default.
• W1566396845 creator A5043758185 @default.
• W1566396845 date "2012-12-01" @default.
• W1566396845 modified "2023-09-24" @default.
• W1566396845 title "Phenotype and function of tumour-derived CD4+ T lymphocytes in colorectal cancer" @default.
• W1566396845 cites W1486722793 @default.
• W1566396845 cites W1499652269 @default.
• W1566396845 cites W1501778305 @default.
• W1566396845 cites W1522859339 @default.
• W1566396845 cites W1537188001 @default.
• W1566396845 cites W1560277370 @default.
• W1566396845 cites W1600457092 @default.
• W1566396845 cites W1603115247 @default.
• W1566396845 cites W1604929343 @default.
• W1566396845 cites W1729103553 @default.
• W1566396845 cites W1824902560 @default.
• W1566396845 cites W1849720919 @default.
• W1566396845 cites W1938157755 @default.
• W1566396845 cites W1966528088 @default.
• W1566396845 cites W1966621240 @default.
• W1566396845 cites W1967376949 @default.
• W1566396845 cites W1967884480 @default.
• W1566396845 cites W1969797237 @default.
• W1566396845 cites W1969825132 @default.
• W1566396845 cites W1973606162 @default.
• W1566396845 cites W1976777395 @default.
• W1566396845 cites W1977476969 @default.
• W1566396845 cites W1978767079 @default.
• W1566396845 cites W1979066356 @default.
• W1566396845 cites W1980920767 @default.
• W1566396845 cites W1984976795 @default.
• W1566396845 cites W1985222144 @default.
• W1566396845 cites W1985532701 @default.
• W1566396845 cites W1986544445 @default.
• W1566396845 cites W1987628377 @default.
• W1566396845 cites W1992699637 @default.
• W1566396845 cites W1995497089 @default.
• W1566396845 cites W1995516336 @default.
• W1566396845 cites W1995744610 @default.
• W1566396845 cites W1997487210 @default.
• W1566396845 cites W2006137635 @default.
• W1566396845 cites W2006249161 @default.
• W1566396845 cites W2006611100 @default.
• W1566396845 cites W2006924771 @default.
• W1566396845 cites W2007442741 @default.
• W1566396845 cites W2008667095 @default.
• W1566396845 cites W2009801524 @default.
• W1566396845 cites W2010011171 @default.
• W1566396845 cites W2010121426 @default.
• W1566396845 cites W2011465764 @default.
• W1566396845 cites W2017654486 @default.
• W1566396845 cites W2022056254 @default.
• W1566396845 cites W2030431013 @default.
• W1566396845 cites W2035050419 @default.
• W1566396845 cites W2036368914 @default.
• W1566396845 cites W2038127214 @default.
• W1566396845 cites W2043398751 @default.
• W1566396845 cites W2044063269 @default.
• W1566396845 cites W2044492878 @default.
• W1566396845 cites W2046182607 @default.
• W1566396845 cites W2047977785 @default.
• W1566396845 cites W2049021995 @default.
• W1566396845 cites W2049782808 @default.
• W1566396845 cites W2051074253 @default.
• W1566396845 cites W2051586643 @default.
• W1566396845 cites W2052493267 @default.
• W1566396845 cites W2053894639 @default.
• W1566396845 cites W2055248228 @default.
• W1566396845 cites W2056581474 @default.
• W1566396845 cites W2058933354 @default.
• W1566396845 cites W2060656939 @default.
• W1566396845 cites W2062811432 @default.
• W1566396845 cites W2071697240 @default.
• W1566396845 cites W2072462773 @default.
• W1566396845 cites W2079892535 @default.
• W1566396845 cites W2081596482 @default.
• W1566396845 cites W2082626794 @default.
• W1566396845 cites W2086196933 @default.
• W1566396845 cites W2093070572 @default.
• W1566396845 cites W2098433563 @default.
• W1566396845 cites W2098992368 @default.
• W1566396845 cites W2103097055 @default.
• W1566396845 cites W2103384599 @default.
• W1566396845 cites W2106789440 @default.
• W1566396845 cites W2107235439 @default.
• W1566396845 cites W2110287677 @default.
• W1566396845 cites W2111728003 @default.
• W1566396845 cites W2111791268 @default.
• W1566396845 cites W2114962227 @default.
• W1566396845 cites W2115415648 @default.
• W1566396845 cites W2116491528 @default.
• W1566396845 cites W2117201337 @default.
• W1566396845 cites W2121708973 @default.
• W1566396845 cites W2123914905 @default.
• W1566396845 cites W2124621398 @default.
• W1566396845 cites W2124841274 @default.
• W1566396845 cites W2125633424 @default.
• W1566396845 cites W2127734125 @default.
• W1566396845 cites W2128277463 @default.

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