FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566451495> ?p ?o ?g. }

• W1566451495 endingPage "20372" @default.
• W1566451495 startingPage "20366" @default.
• W1566451495 abstract "Effect of heat shock on a glutathione-synthesizing enzyme, gamma-glutamylcysteine synthetase (gamma-GCS), and ATP-dependent outward transport of glutathione S-conjugate was characterized using K562 erythroid cells. When K562 cells grown at 37 degrees C were shifted to 42 degrees C for 2 h, an approximate 1.7-fold increase in the activity of gamma-GCS was observed. Treatment of K562 cells with erythropoietin (EP) for 12 h resulted in a decrease in the activity of gamma-GCS to 64% of the control. However, responsiveness of this enzyme activity in the cells treated with EP to heat shock was similar to that in untreated cells. Changes in the immunological activity of gamma-GCS were also observed in parallel with those in the enzymatic activity. On Northern blot analysis of total RNAs isolated from the cells with human cDNA for gamma-GCS, a substantial induction of mRNA level was found by heat shock and a reduction of EP. These changes were modest but correlated to the mRNA expression of a heat shock protein, HSP 70. Heat shock also had an effect of 1.8-fold stimulation on glutathione S-conjugate transport in K562 cells previously incubated with 1-chloro-2,4-dinitrobenzene. Treatment of the cells with EP resulted in a decrease in this transport by 62%. Similarly, the levels of glutathione S-conjugate-stimulated Mg(2+)-ATPase, which enzyme is thought to be involved in the transport of glutathione S-conjugate, were responsive to heat shock and EP. These results suggest that glutathione synthesis and transport process of glutathione metabolites are responsive to heat shock and play a role in the defense system against stresses. It is also suggested that the regulatory site of the expression of these enzymes by heat shock is independent of that by EP." @default.
• W1566451495 created "2016-06-24" @default.
• W1566451495 creator A5003373495 @default.
• W1566451495 creator A5009365947 @default.
• W1566451495 creator A5036745181 @default.
• W1566451495 creator A5044178319 @default.
• W1566451495 creator A5066969352 @default.
• W1566451495 creator A5081174788 @default.
• W1566451495 date "1993-09-01" @default.
• W1566451495 modified "2023-09-29" @default.
• W1566451495 title "gamma-Glutamylcysteine synthetase and active transport of glutathione S-conjugate are responsive to heat shock in K562 erythroid cells." @default.
• W1566451495 cites W1199623702 @default.
• W1566451495 cites W1531100917 @default.
• W1566451495 cites W1535345009 @default.
• W1566451495 cites W1549277283 @default.
• W1566451495 cites W1562066535 @default.
• W1566451495 cites W1932806396 @default.
• W1566451495 cites W1966999658 @default.
• W1566451495 cites W1968209090 @default.
• W1566451495 cites W1978183355 @default.
• W1566451495 cites W1981613306 @default.
• W1566451495 cites W1996257794 @default.
• W1566451495 cites W2014892567 @default.
• W1566451495 cites W2028265608 @default.
• W1566451495 cites W2035122341 @default.
• W1566451495 cites W2043033368 @default.
• W1566451495 cites W2057204560 @default.
• W1566451495 cites W2057271651 @default.
• W1566451495 cites W2064425735 @default.
• W1566451495 cites W2071756286 @default.
• W1566451495 cites W2072344627 @default.
• W1566451495 cites W2073488597 @default.
• W1566451495 cites W2078471960 @default.
• W1566451495 cites W2100837269 @default.
• W1566451495 cites W2119393061 @default.
• W1566451495 cites W2125876729 @default.
• W1566451495 cites W2153247725 @default.
• W1566451495 cites W2163143933 @default.
• W1566451495 cites W2168914999 @default.
• W1566451495 cites W937093307 @default.
• W1566451495 doi "https://doi.org/10.1016/s0021-9258(20)80737-6" @default.
• W1566451495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8104187" @default.
• W1566451495 hasPublicationYear "1993" @default.
• W1566451495 type Work @default.
• W1566451495 sameAs 1566451495 @default.
• W1566451495 citedByCount "79" @default.
• W1566451495 countsByYear W15664514952013 @default.
• W1566451495 countsByYear W15664514952020 @default.
• W1566451495 countsByYear W15664514952021 @default.
• W1566451495 countsByYear W15664514952023 @default.
• W1566451495 crossrefType "journal-article" @default.
• W1566451495 hasAuthorship W1566451495A5003373495 @default.
• W1566451495 hasAuthorship W1566451495A5009365947 @default.
• W1566451495 hasAuthorship W1566451495A5036745181 @default.
• W1566451495 hasAuthorship W1566451495A5044178319 @default.
• W1566451495 hasAuthorship W1566451495A5066969352 @default.
• W1566451495 hasAuthorship W1566451495A5081174788 @default.
• W1566451495 hasBestOaLocation W15664514951 @default.
• W1566451495 hasConcept C104317684 @default.
• W1566451495 hasConcept C126322002 @default.
• W1566451495 hasConcept C134306372 @default.
• W1566451495 hasConcept C153911025 @default.
• W1566451495 hasConcept C171122931 @default.
• W1566451495 hasConcept C181199279 @default.
• W1566451495 hasConcept C185592680 @default.
• W1566451495 hasConcept C197336794 @default.
• W1566451495 hasConcept C2781300812 @default.
• W1566451495 hasConcept C33923547 @default.
• W1566451495 hasConcept C538909803 @default.
• W1566451495 hasConcept C55493867 @default.
• W1566451495 hasConcept C71924100 @default.
• W1566451495 hasConcept C86803240 @default.
• W1566451495 hasConcept C95444343 @default.
• W1566451495 hasConceptScore W1566451495C104317684 @default.
• W1566451495 hasConceptScore W1566451495C126322002 @default.
• W1566451495 hasConceptScore W1566451495C134306372 @default.
• W1566451495 hasConceptScore W1566451495C153911025 @default.
• W1566451495 hasConceptScore W1566451495C171122931 @default.
• W1566451495 hasConceptScore W1566451495C181199279 @default.
• W1566451495 hasConceptScore W1566451495C185592680 @default.
• W1566451495 hasConceptScore W1566451495C197336794 @default.
• W1566451495 hasConceptScore W1566451495C2781300812 @default.
• W1566451495 hasConceptScore W1566451495C33923547 @default.
• W1566451495 hasConceptScore W1566451495C538909803 @default.
• W1566451495 hasConceptScore W1566451495C55493867 @default.
• W1566451495 hasConceptScore W1566451495C71924100 @default.
• W1566451495 hasConceptScore W1566451495C86803240 @default.
• W1566451495 hasConceptScore W1566451495C95444343 @default.
• W1566451495 hasIssue "27" @default.
• W1566451495 hasLocation W15664514951 @default.
• W1566451495 hasOpenAccess W1566451495 @default.
• W1566451495 hasPrimaryLocation W15664514951 @default.
• W1566451495 hasRelatedWork W1993590950 @default.
• W1566451495 hasRelatedWork W2033949303 @default.
• W1566451495 hasRelatedWork W2148948361 @default.
• W1566451495 hasRelatedWork W2177354757 @default.
• W1566451495 hasRelatedWork W2230138890 @default.
• W1566451495 hasRelatedWork W2949098585 @default.

• next