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• W1566451887 abstract "Abstract The administration of a preparation of desiccated thyroid in 20 or 25 grain dosages to healthy adult male prisoners was associated with increases in the mean daily urine volume, mean daily creatinine clearance and, sporadically, with an appearance or accentuation of creatinuria. Urine calcium and phosphorus excretion also appeared to increase but the changes were not statistically significant. The origins of the trends to hypercalciuria and hyperphosphaturia cannot be identified because balance data are lacking, but presumably variables such as the increased intake of food and the loss of skeletal calcium and phosphorus which characterize thyrotoxicosis were operative. The tubular reabsorption of filtered phosphorus remained constant. The daily excretion of urinary Porter-Silber chromogens increased, while the 17-ketosteroids remained constant. The comparable responses to mepyrapone (Metopirone or SU 4885) prior to and during thyroid administration indicate that pituitary-adrenal responsiveness had not been altered by this therapy. The decrease in the urinary 17-ketosteroid and perhaps the compound S responses to exogenous ACTH in our studies indicates that the secretion, conversion, or excretion of these classes of steroids is altered by induced excesses of thyroid hormone. The urinary Porter-Silber chromogen response to exogenous ACTH was not altered. Urinary gonadotropins decreased during treatment with large dosages of thyroid hormone. Total and free hydroxyproline excretion in urine increased during administration of desiccated thyroid in large dosages." @default.
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• W1566451887 date "1964-08-01" @default.
• W1566451887 modified "2023-09-29" @default.
• W1566451887 title "Hydrocortisone and/or desiccated thyroid in physiologic dosage" @default.
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• W1566451887 doi "https://doi.org/10.1016/0026-0495(64)90018-6" @default.
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