FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566517540> ?p ?o ?g. }

• W1566517540 abstract "Synaptic dynamics are critical to the function of neuronal circuits on multiple timescales. In the first part of this dissertation, I tested the roles of action potential timing and NMDA receptor composition in long-term modifications to synaptic efficacy. In a computational model I showed that the dynamics of the postsynaptic [Ca2+] time course can be used to map the timing of pre- and postsynaptic action potentials onto experimentally observed changes in synaptic strength. Using dual patch-clamp recordings from cultured hippocampal neurons, I found that NMDAR subtypes can map combinations of pre- and postsynaptic action potentials onto either long-term potentiation (LTP) or depression (LTD). LTP and LTD could even be evoked by the same stimuli, and in such cases the plasticity outcome was determined by the availability of NMDAR subtypes. The expression of LTD was increasingly presynaptic as synaptic connections became more developed. Finally, I found that spike-timing-dependent potentiability is history-dependent, with a non-linear relationship to the number of pre- and postsynaptic action potentials. After LTP induction, subsequent potentiability recovered on a timescale of minutes, and was dependent on the duration of the previous induction. While activity-dependent plasticity is putatively involved in circuit development, I found that it was not required to produce small networks capable of exhibiting rhythmic persistent activity patterns called reverberations. However, positive synaptic scaling produced by network inactivity yielded increased quantal synaptic amplitudes, connectivity, and potentiability, all favoring reverberation. These data suggest that chronic inactivity upregulates synaptic efficacy by both quantal amplification and by the addition of silent synapses, the latter of which are rapidly activated by reverberation. Reverberation in previously inactivated networks also resulted in activity-dependent outbreaks of spontaneous network activity. Applying a model of short-term synaptic dynamics to the network level, I argue that these experimental observations can be explained by the interaction between presynaptic calcium dynamics and short-term synaptic depression on multiple timescales. Together, the experiments and modeling indicate that ongoing activity, synaptic scaling and metaplasticity are required to endow networks with a level of synaptic connectivity and potentiability that supports stimulus-evoked persistent activity patterns but avoids spontaneous activity." @default.
• W1566517540 created "2016-06-24" @default.
• W1566517540 creator A5020632492 @default.
• W1566517540 date "2008-04-18" @default.
• W1566517540 modified "2023-09-27" @default.
• W1566517540 title "Synaptic plasticity and Hebbian cell assemblies" @default.
• W1566517540 cites W133569429 @default.
• W1566517540 cites W146465976 @default.
• W1566517540 cites W1481927180 @default.
• W1566517540 cites W1483876599 @default.
• W1566517540 cites W1486852018 @default.
• W1566517540 cites W1489219269 @default.
• W1566517540 cites W1489333352 @default.
• W1566517540 cites W1498038217 @default.
• W1566517540 cites W1507029368 @default.
• W1566517540 cites W1514853588 @default.
• W1566517540 cites W1530479094 @default.
• W1566517540 cites W1531424821 @default.
• W1566517540 cites W1531436913 @default.
• W1566517540 cites W1532576817 @default.
• W1566517540 cites W1540069135 @default.
• W1566517540 cites W1548516628 @default.
• W1566517540 cites W1555048537 @default.
• W1566517540 cites W156016587 @default.
• W1566517540 cites W1564150153 @default.
• W1566517540 cites W1567391514 @default.
• W1566517540 cites W1569065316 @default.
• W1566517540 cites W1575357711 @default.
• W1566517540 cites W1575372500 @default.
• W1566517540 cites W1577778731 @default.
• W1566517540 cites W1589692855 @default.
• W1566517540 cites W1591829725 @default.
• W1566517540 cites W1606363443 @default.
• W1566517540 cites W1633727833 @default.
• W1566517540 cites W1642181682 @default.
• W1566517540 cites W1733248925 @default.
• W1566517540 cites W1735445987 @default.
• W1566517540 cites W1774348706 @default.
• W1566517540 cites W181224029 @default.
• W1566517540 cites W1836848727 @default.
• W1566517540 cites W1869401664 @default.
• W1566517540 cites W1875306972 @default.
• W1566517540 cites W1876061808 @default.
• W1566517540 cites W1889678891 @default.
• W1566517540 cites W1894307146 @default.
• W1566517540 cites W1898334791 @default.
• W1566517540 cites W1907121963 @default.
• W1566517540 cites W191870887 @default.
• W1566517540 cites W1940417817 @default.
• W1566517540 cites W1957331510 @default.
• W1566517540 cites W1964647417 @default.
• W1566517540 cites W1966474984 @default.
• W1566517540 cites W1966478172 @default.
• W1566517540 cites W1967059763 @default.
• W1566517540 cites W1967302106 @default.
• W1566517540 cites W1967878023 @default.
• W1566517540 cites W1968581566 @default.
• W1566517540 cites W1968687601 @default.
• W1566517540 cites W1968911801 @default.
• W1566517540 cites W1969159701 @default.
• W1566517540 cites W1970006557 @default.
• W1566517540 cites W1971734119 @default.
• W1566517540 cites W1972270334 @default.
• W1566517540 cites W1972649124 @default.
• W1566517540 cites W1973436856 @default.
• W1566517540 cites W1973533307 @default.
• W1566517540 cites W1974217719 @default.
• W1566517540 cites W1976175452 @default.
• W1566517540 cites W1976697257 @default.
• W1566517540 cites W1977177901 @default.
• W1566517540 cites W1977397789 @default.
• W1566517540 cites W1979317467 @default.
• W1566517540 cites W1979586675 @default.
• W1566517540 cites W1981195606 @default.
• W1566517540 cites W1982073244 @default.
• W1566517540 cites W1982118871 @default.
• W1566517540 cites W1982785464 @default.
• W1566517540 cites W1983234453 @default.
• W1566517540 cites W1983350404 @default.
• W1566517540 cites W1983504750 @default.
• W1566517540 cites W1983699648 @default.
• W1566517540 cites W1984398032 @default.
• W1566517540 cites W1984702255 @default.
• W1566517540 cites W1984989740 @default.
• W1566517540 cites W1985079872 @default.
• W1566517540 cites W1985322212 @default.
• W1566517540 cites W1985600786 @default.
• W1566517540 cites W1986291163 @default.
• W1566517540 cites W1987700551 @default.
• W1566517540 cites W1987832351 @default.
• W1566517540 cites W1987967341 @default.
• W1566517540 cites W1988007470 @default.
• W1566517540 cites W1990220309 @default.
• W1566517540 cites W1990501032 @default.
• W1566517540 cites W1990625157 @default.
• W1566517540 cites W1991222835 @default.
• W1566517540 cites W1991779336 @default.
• W1566517540 cites W1992226873 @default.
• W1566517540 cites W1993132909 @default.
• W1566517540 cites W1993856738 @default.

• next