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- W1566534047 abstract "A confluence is the merger or meeting of two or more objects (or subject matters) that seem to inseparably bind their respective forces or attributes into a point of junction. The point of junction of pharmacometric knowledge discovery and creation is in attempting to gain knowledge and understanding of the response surface, especially an unexplored region. Thus, the importance of using a combination of pharmacometrics (PM) knowledge discovery and creation approaches in characterizing an aspect of the response surface in terms drug safety has been discussed. An overview of some techniques for pharmacometric knowledge discovery has been presented together with the introduction of a new metric, the percentile division approach, for data structure revelation; and a new metric (the percentage duration of an AE) for analyzing drug induced AE has been proposed. The application example demonstrates the confluence of PM knowledge discovery and creation in drug development." @default.
- W1566534047 created "2016-06-24" @default.
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- W1566534047 date "2006-05-18" @default.
- W1566534047 modified "2023-10-16" @default.
- W1566534047 title "The Confluence of Pharmacometric Knowledge Discovery and Creation in the Characterization of Drug Safety" @default.
- W1566534047 doi "https://doi.org/10.1002/9780470087978.ch47" @default.
- W1566534047 hasPublicationYear "2006" @default.
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