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• W1566556189 abstract "This chapter focuses on the development and use of protein chimeras (derived from proteins naturally present in the medusa, aequorea victoria) that are specifically targeted to the mitochondria, either to the matrix or to the intermembrane space, and can be used to monitor calcium and pH. Aequorin, the pioneer of the targeted recombinant probes, is a Ca2+-sensitive photoprotein that emits light on binding of Ca2+ to its three high affinities Ca2+-binding sites. The chapter describes the use of mutants of green fluorescent protein as Ca2+ and pH probes. Genetically encoded biosensors (chimeric proteins) are intracellular probes of physiological parameters endowed with unique advantages. The advantages include the ability to measure intracellular parameters (such as Ca2+and pH) at specific intracellular sites, with little background signal and no probe leakage. Additionally, the use of biosensors is not associated with the toxicity observes with many chemical probes nor with the need of invasive loading procedures. Furthermore, an ideal intracellular probe should be stable, have high parameter sensitivity and specificity, rapid signal response to parameter changes, and good luminescent/optical properties." @default.
• W1566556189 created "2016-06-24" @default.
• W1566556189 creator A5015723692 @default.
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• W1566556189 creator A5070894673 @default.
• W1566556189 date "2007-01-01" @default.
• W1566556189 modified "2023-10-04" @default.
• W1566556189 title "Biosensors for the Detection of Calcium and pH" @default.
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• W1566556189 doi "https://doi.org/10.1016/s0091-679x(06)80015-4" @default.
• W1566556189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17445701" @default.
• W1566556189 hasPublicationYear "2007" @default.
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