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- W1566579973 abstract "Background: Associations between HDL efflux capacity, HDL particle number and carotid artery wall thickness have been reported. It is unclear if HDL efflux capacity and particle number are associated with the presence of carotid lipid rich necrotic core (LRNC), a marker of high-risk atherosclerosis. Methods: We performed carotid magnetic resonance imaging (MR) in 402 Chicago Healthy Aging Study participants (ppts). HDL and LDL particle number were measured with NMR spectroscopy. HDL efflux capacity was measured using a validated ex vivo tissue culture assay. We assessed cross-sectional associations between HDL particle number, LDL particle number, HDL efflux capacity and LRNC in separate logistic regression models. Results: Mean age of ppts included in this analysis was 73 years and 66% were men; 23% had LRNC. Compared to those without LRNC, ppts with LRNC had significantly lower HDL-C (52 vs. 59 mg/dL p=0.001), higher fasting glucose (103 vs. 99 mg/dL p=0.005) higher triglycerides (119 vs. 101 mg/dL p=0...." @default.
- W1566579973 created "2016-06-24" @default.
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- W1566579973 date "2015-03-10" @default.
- W1566579973 modified "2023-09-23" @default.
- W1566579973 title "Abstract P223: HDL Efflux Capacity, HDL Particle Number, and Carotid Artery Lipid Rich Necrotic Core Plaque: The Chicago Healthy Aging Study" @default.
- W1566579973 hasPublicationYear "2015" @default.
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