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- W1566581490 endingPage "1045" @default.
- W1566581490 startingPage "1029" @default.
- W1566581490 abstract "Migraine is a neurovascular disorder, and although the pathophysiology of migraine has not been fully delineated, much has been learned in the past 50 years. This knowledge has been accompanied by significant advancements in the way migraine is viewed as a disease process and in the development therapeutic options. In this review, we will focus on 4 mediators (nitric oxide, histamine, serotonin, and calcitonin gene-related peptide) which have significantly advanced our understanding of migraine as a disease entity. For each mediator we begin by reviewing the preclinical data linking it to migraine pathophysiology, first focusing on the vascular mechanisms, then the neuronal mechanisms. The preclinical data are then followed by a review of the clinical data which support each mediator's role in migraine and highlights the pharmacological agents which target these mediators for migraine therapy." @default.
- W1566581490 created "2016-06-24" @default.
- W1566581490 creator A5011071065 @default.
- W1566581490 creator A5032147468 @default.
- W1566581490 creator A5049092477 @default.
- W1566581490 date "2011-06-01" @default.
- W1566581490 modified "2023-10-16" @default.
- W1566581490 title "Chemical Mediators of Migraine: Preclinical and Clinical Observations" @default.
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