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- W1566582855 abstract "The amino acid composition of amniotic fluid samples obtained from 51 patients at various stages of fetal gestation was determined by column chromatography. There is a decreasing concentration of most of the amino acids with increasing gestational age. The maximum rate of this decrease occurs between the twenty-second and the twenty-fourth week of pregnancy. As it is well established that the offspring of women with phenylketonuria (PKU) will have in most cases intrauterine and postnatal growth retardation, mental retardation, and/or structural abnormalities, amniotic fluid samples from 2 pregnancies of a woman affected with PKU were also analyzed. In both pregnancies (eighth and fortieth weeks of gestation) the amniotic fluid phenylalanine concentration was elevated to about 35 times that of normal." @default.
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- W1566582855 date "1971-09-01" @default.
- W1566582855 modified "2023-09-23" @default.
- W1566582855 title "Developmental changes in amino acid concentrations in human amniotic fluid: Abnormal findings in maternal phenylketonuria" @default.
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- W1566582855 doi "https://doi.org/10.1016/0002-9378(71)90923-9" @default.
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