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• W1566588664 abstract "Stress can have profound effects on the cell. The elicitation of the stress response in the cell is often accompanied by the synthesis of high-molecular-mass complexes, sometimes termed heat shock granules (HSGs). The presence of the complexes has been shown to be important for the survival of cells subjected to stress. We purified these complexes from heat-stressed BY-2 tobacco cells. HSG complexes formed in vivo contain predominantly smHSPs, HSP40 and HSP70 and display chaperone-like activity. Tubulins as well as other proteins may be part of the complex or its substrate. The proteins, except smHSPs and to some extent HSP70, were hypersensitive to proteolysis, suggesting that they were partially denatured and not an integral part of the HSG complexes. When citrate synthase was used as the substrate, in vivo generated HSG complexes exhibited strong nucleotide-dependent in vitro chaperone activity. Measurable ATP-mediated hydrolytic activity was detected. Isolated HSG complexes are stable until ATP is added, which leads to rapid dissociation of the complex into subunits. It is proposed that smHSPs form the core of the complex in association with ATP-dependent HSP70 and HSP40 cochaperones. Implications of these findings are discussed." @default.
• W1566588664 created "2016-06-24" @default.
• W1566588664 creator A5013066355 @default.
• W1566588664 creator A5021210826 @default.
• W1566588664 creator A5071008130 @default.
• W1566588664 date "2000-04-01" @default.
• W1566588664 modified "2023-10-11" @default.
• W1566588664 title "High-molecular-mass complexes formed in vivo contain smHSPs and HSP70 and display chaperone-like activity" @default.
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• W1566588664 doi "https://doi.org/10.1046/j.1432-1327.2000.01223.x" @default.
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