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- W1566590913 abstract "The sites of transferrin synthesis and the factors affecting synthesis were investigated in the rat by measuring the incorporation of 14C-leucine into transferrin, albumin, and γG-globulin precipitated with specific antisera. Twenty minutes after the intravenous injection of 14C-leucine, the radioactivity was incorporated into microsomal transferrin of liver in much greater amounts than into that of other tissues. After incubation of tissue slices with 14C-leucine in vitro, however, radioactivity was incorporated into transferrin by liver, spleen, and bone marrow at about the same rates per unit per weight of tissue. Because of its greatest bulk, the liver again appeared to be by far the most important organ for transferrin synthesis. The incorporation of 14C-leucine into transferrin and albumin by liver slices was used as a measure of synthesis of the proteins. Transferrin synthesis was increased in rats with hemorrhagic iron deficiency anemia and in rats treated with thyroxine or exposed to reduced atmospheric pressure. Prior treatment of rats with 100 µg of actinomycin D per 100 g of body weight did not prevent the increase in transferrin synthesis produced by exposure to reduced atmospheric pressure. Decreased synthesis was found with liver from rats with transfusional polycythemia, fasted rats, and rats given propylthiouracil. Thyroxine and propylthiouracil treatment and fasting had similar effects on albumin synthesis, but the other treatments had no effect. Iron loading with iron-dextran and acute and chronic hemolytic anemia produced with phenylhydrazine and methyl cellulose, respectively, resulted in little change in transferrin synthesis by liver slices." @default.
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- W1566590913 date "1969-08-01" @default.
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- W1566590913 title "Factors Affecting the Synthesis of Transferrin by Rat Tissue Slices" @default.
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- W1566590913 doi "https://doi.org/10.1016/s0021-9258(17)36401-3" @default.
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