Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566594410> ?p ?o ?g. }
- W1566594410 endingPage "1276" @default.
- W1566594410 startingPage "1265" @default.
- W1566594410 abstract "Abstract Npas3 is a member of the bHLH‐PAS superfamily of transcription factors that is expressed broadly in the developing neuroepithelium. To study the function of this gene, mice deficient in Npas3 were generated and characterized. Npas3 –/– mice were growth‐retarded and exhibited developmental brain abnormalities that included a reduction in size of the anterior hippocampus, hypoplasia of the corpus callosum and enlargement of the ventricles. A number of behavioural abnormalities were identified in Npas3 –/– mice including locomotor hyperactivity, subtle gait defects, impairment of prepulse inhibition of acoustic startle, deficit in recognition memory and altered anxiety‐related responses. Characterization of neurosignaling pathways using several pharmacological agents revealed dysfunctional glutamate, dopamine and serotonin neurotransmitter signaling. Consistent with these findings, we identified a significant alteration in cortical PSD‐95 expression, a PDZ‐containing protein that has been shown to be involved in postsynaptic signal transduction. Together, our observations indicate an important role for Npas3 in controlling normal brain development and neurosignaling pathways." @default.
- W1566594410 created "2016-06-24" @default.
- W1566594410 creator A5001922046 @default.
- W1566594410 creator A5008279572 @default.
- W1566594410 creator A5017775899 @default.
- W1566594410 creator A5018880628 @default.
- W1566594410 creator A5021563072 @default.
- W1566594410 creator A5037432541 @default.
- W1566594410 creator A5063310059 @default.
- W1566594410 creator A5065603759 @default.
- W1566594410 creator A5089828912 @default.
- W1566594410 date "2005-09-01" @default.
- W1566594410 modified "2023-10-15" @default.
- W1566594410 title "Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice" @default.
- W1566594410 cites W1479747866 @default.
- W1566594410 cites W1542397258 @default.
- W1566594410 cites W1599299698 @default.
- W1566594410 cites W1963956528 @default.
- W1566594410 cites W1966697925 @default.
- W1566594410 cites W1972419595 @default.
- W1566594410 cites W1982720888 @default.
- W1566594410 cites W1983424191 @default.
- W1566594410 cites W1988836643 @default.
- W1566594410 cites W1990888488 @default.
- W1566594410 cites W1991004364 @default.
- W1566594410 cites W2001308670 @default.
- W1566594410 cites W2006780438 @default.
- W1566594410 cites W2009132775 @default.
- W1566594410 cites W2010840481 @default.
- W1566594410 cites W2014793858 @default.
- W1566594410 cites W2037400256 @default.
- W1566594410 cites W2039710055 @default.
- W1566594410 cites W2040804871 @default.
- W1566594410 cites W2041574124 @default.
- W1566594410 cites W2042676846 @default.
- W1566594410 cites W2043433914 @default.
- W1566594410 cites W2047841570 @default.
- W1566594410 cites W2048920034 @default.
- W1566594410 cites W2051905619 @default.
- W1566594410 cites W2052713474 @default.
- W1566594410 cites W2054315438 @default.
- W1566594410 cites W2064193818 @default.
- W1566594410 cites W2067203788 @default.
- W1566594410 cites W2075683381 @default.
- W1566594410 cites W2079882316 @default.
- W1566594410 cites W2084395458 @default.
- W1566594410 cites W2087987954 @default.
- W1566594410 cites W2088239473 @default.
- W1566594410 cites W2092216786 @default.
- W1566594410 cites W2092707982 @default.
- W1566594410 cites W2094611185 @default.
- W1566594410 cites W2107522917 @default.
- W1566594410 cites W2108387565 @default.
- W1566594410 cites W2117242960 @default.
- W1566594410 cites W2126440176 @default.
- W1566594410 cites W2141166900 @default.
- W1566594410 cites W2144392815 @default.
- W1566594410 cites W2145111083 @default.
- W1566594410 cites W2145766592 @default.
- W1566594410 cites W2151068043 @default.
- W1566594410 cites W2155704304 @default.
- W1566594410 cites W2158490907 @default.
- W1566594410 cites W2164606563 @default.
- W1566594410 cites W2164674870 @default.
- W1566594410 cites W2171501632 @default.
- W1566594410 doi "https://doi.org/10.1111/j.1460-9568.2005.04291.x" @default.
- W1566594410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16190882" @default.
- W1566594410 hasPublicationYear "2005" @default.
- W1566594410 type Work @default.
- W1566594410 sameAs 1566594410 @default.
- W1566594410 citedByCount "70" @default.
- W1566594410 countsByYear W15665944102012 @default.
- W1566594410 countsByYear W15665944102013 @default.
- W1566594410 countsByYear W15665944102014 @default.
- W1566594410 countsByYear W15665944102015 @default.
- W1566594410 countsByYear W15665944102016 @default.
- W1566594410 countsByYear W15665944102017 @default.
- W1566594410 countsByYear W15665944102018 @default.
- W1566594410 countsByYear W15665944102019 @default.
- W1566594410 countsByYear W15665944102020 @default.
- W1566594410 countsByYear W15665944102021 @default.
- W1566594410 countsByYear W15665944102022 @default.
- W1566594410 crossrefType "journal-article" @default.
- W1566594410 hasAuthorship W1566594410A5001922046 @default.
- W1566594410 hasAuthorship W1566594410A5008279572 @default.
- W1566594410 hasAuthorship W1566594410A5017775899 @default.
- W1566594410 hasAuthorship W1566594410A5018880628 @default.
- W1566594410 hasAuthorship W1566594410A5021563072 @default.
- W1566594410 hasAuthorship W1566594410A5037432541 @default.
- W1566594410 hasAuthorship W1566594410A5063310059 @default.
- W1566594410 hasAuthorship W1566594410A5065603759 @default.
- W1566594410 hasAuthorship W1566594410A5089828912 @default.
- W1566594410 hasConcept C118552586 @default.
- W1566594410 hasConcept C141421786 @default.
- W1566594410 hasConcept C15744967 @default.
- W1566594410 hasConcept C169760540 @default.
- W1566594410 hasConcept C170493617 @default.
- W1566594410 hasConcept C197341189 @default.