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- W156659761 abstract "This chapter describes the function of the voltage-gated Na + channel and its metabolic regulation, at concentrated on modulation and defects in molecular function. Activation of Na + channels is believed to result from a voltage-driven conformational change, which opens a transmembrane pore through the protein. Channel opening is triggered by membrane depolarization, exerting an electrical force on the voltage sensor located within the transmembrane electrical field of the S4 segment in each domain. The movement of the gating charges through the membrane is directly measured as an outward gating current. Studies of the cardiac Na + channel at the molecular level utilizing the patch-clamp technique and a recombinant expression system shed light on the process of how the Na + channel behaves in terms of molecular function in physiological and pathophysiological situations. The discovery of the Na + channel gene defects that cause LQT and Brugada syndromes represents a major advancement in the field. The powerful combination of molecular genetics with detailed studies of the structure and function of recombinant Na + channels can provide insight into the mechanistic factors that cause the clinical phenotypes of many inherited diseases related to the Na + channel. It also offers the possibility of developing specific therapeutic approaches to disease management that are based on the specific functional properties of the Na + channel in physiological and pathophysiological conditions." @default.
- W156659761 created "2016-06-24" @default.
- W156659761 creator A5073134409 @default.
- W156659761 creator A5079938599 @default.
- W156659761 date "2001-01-01" @default.
- W156659761 modified "2023-09-23" @default.
- W156659761 title "Sodium Channels" @default.
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