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- W1566600743 abstract "Cognitive decline in Alzheimer's disease (AD) occurs as a result of the buildup of pathological proteins and downstream events including an elevated and altered inflammatory response. Inflammation has previously been linked to increased abnormal phosphorylation of tau protein. To determine if endogenous amyloid-beta (Abeta)-induced neuroinflammation drives tau phosphorylation in vivo, we treated 8-month-old 3xTg-AD with minocycline, an anti-inflammatory agent, to assess how it influenced cognitive decline and development of pathology. 4 months of treatment restored cognition to non-transgenic performance. Inflammatory profiling revealed a marked decrease in GFAP, TNFalpha, and IL6 and an increase in the CXCL1 chemokines KC and MIP1a. Minocycline also reduced levels of insoluble Abeta and soluble fibrils. Despite reducing levels of the tau kinase cdk5 coactivator p25, minocycline did not have wide effects on tau pathology with only one phospho-epitope showing reduction with treatment (S212/S214). The sum of these findings shows that reduction of the inflammatory events in an AD mouse model prevents cognitive deficits associated with pathology, but that endogenous Abeta-derived neuroinflammation does not contribute significantly to the development of tau pathology." @default.
- W1566600743 created "2016-06-24" @default.
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- W1566600743 date "2010-08-11" @default.
- W1566600743 modified "2023-09-24" @default.
- W1566600743 title "Reductions in Amyloid-β-Derived Neuroinflammation, with Minocycline, Restore Cognition but do not Significantly Affect Tau Hyperphosphorylation" @default.
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- W1566600743 cites W1536117213 @default.
- W1566600743 cites W1542136448 @default.
- W1566600743 cites W171292389 @default.
- W1566600743 cites W1966815691 @default.
- W1566600743 cites W1967061503 @default.
- W1566600743 cites W1967464880 @default.
- W1566600743 cites W1967693560 @default.
- W1566600743 cites W1968764682 @default.
- W1566600743 cites W1971207561 @default.
- W1566600743 cites W1972891705 @default.
- W1566600743 cites W1973276273 @default.
- W1566600743 cites W1976445933 @default.
- W1566600743 cites W1976845082 @default.
- W1566600743 cites W1985164067 @default.
- W1566600743 cites W1986830236 @default.
- W1566600743 cites W1992598058 @default.
- W1566600743 cites W1993589138 @default.
- W1566600743 cites W1993862136 @default.
- W1566600743 cites W1998981667 @default.
- W1566600743 cites W2001210466 @default.
- W1566600743 cites W2002510458 @default.
- W1566600743 cites W2005415928 @default.
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- W1566600743 cites W2015570166 @default.
- W1566600743 cites W2017260345 @default.
- W1566600743 cites W2021374516 @default.
- W1566600743 cites W2022433310 @default.
- W1566600743 cites W2036717742 @default.
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- W1566600743 cites W2040536037 @default.
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- W1566600743 cites W2043605366 @default.
- W1566600743 cites W2044445029 @default.
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- W1566600743 cites W2074455856 @default.
- W1566600743 cites W2075725519 @default.
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- W1566600743 cites W2095456987 @default.
- W1566600743 cites W2097281218 @default.
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- W1566600743 cites W2103428562 @default.
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- W1566600743 doi "https://doi.org/10.3233/jad-2010-100204" @default.
- W1566600743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4085054" @default.
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