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• W1566609595 abstract "Summary Aims Preconditioning is promising for treating cerebral ischemic stroke. Annexin A1 ( ANXA 1) is a homeostatic antiinflammatory mediator that participates in countering against ischemic injuries. We investigated whether chloral hydrate preconditioning ( CH ) exerts neuroprotection via regulation of ANXA 1 in stroke. Methods Adult male C57 BL /6J mice or ANXA 1 knockout ( ANXA 1 −/− ) mice were randomly allocated to control ( NCH ) and CH groups [2%, 6%, and 10% chloral hydrate ( i.p .) 1 h before the middle cerebral artery occlusion ( MCAO )]. Neurological performances were evaluated by modified 7‐point neurological scales and rotarod test. Cerebral infarction was analyzed by triphenyltetrazolium chloride ( TTC ) staining and MRI . The expression of ANXA 1, pro‐inflammatory ( TNF ‐ α , IL ‐1 β , IL ‐6), and antiinflammatory ( IL ‐4, IL ‐10, TGF ‐ β ) cytokines was investigated by RT ‐ PCR , western blot, and immunofluorescence. Results Chloral hydrate preconditioning significantly improved the neurological outcomes and reduced the infarction and brain edema after ischemia. In addition, CH increased the expression of ANXA 1 in the microglia, decreased the levels of TNF ‐ α , IL ‐1 β , and IL ‐6, while elevated the levels of IL ‐4, IL ‐10, and TGF ‐ β in the MCAO mice. Furthermore, both ANXA 1 blocker Boc1 (5 mg/kg, i.c.v .) or ANXA 1 gene deficiency restrained the protective effects of CH against stroke. Conclusions Chloral hydrate preconditioning protects against ischemic injuries through upregulating the expression of ANXA 1, and the followed antiinflammatory mechanisms." @default.
• W1566609595 created "2016-06-24" @default.
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• W1566609595 date "2015-07-24" @default.
• W1566609595 modified "2023-10-17" @default.
• W1566609595 title "Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1" @default.
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• W1566609595 doi "https://doi.org/10.1111/cns.12435" @default.
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