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- W1566641143 endingPage "1518" @default.
- W1566641143 startingPage "1509" @default.
- W1566641143 abstract "The musculoskeletal system evolved in mammals to perform diverse functions that include locomotion, facilitating breathing, protecting internal organs, and coordinating global energy expenditure. Bone and skeletal muscles involved with locomotion are both derived from somitic mesoderm and accumulate peak tissue mass synchronously, according to genetic information and environmental stimuli. Aging results in the progressive and parallel loss of bone (osteopenia) and skeletal muscle (sarcopenia) with profound consequences for quality of life. Age-associated sarcopenia results in reduced endurance, poor balance, and reduced mobility that predispose elderly individuals to falls, which more frequently result in fracture because of concomitant osteoporosis. Thus, a better understanding of the mechanisms underlying the parallel development and involution of these tissues is critical to developing new and more effective means to combat osteoporosis and sarcopenia in our increasingly aged population. This perspective highlights recent advances in our understanding of mechanisms coupling bone and skeletal muscle mass, and identify critical areas where further work is needed." @default.
- W1566641143 created "2016-06-24" @default.
- W1566641143 creator A5016202341 @default.
- W1566641143 creator A5023794859 @default.
- W1566641143 creator A5054458876 @default.
- W1566641143 date "2013-06-18" @default.
- W1566641143 modified "2023-09-23" @default.
- W1566641143 title "Bone and Skeletal Muscle: Neighbors With Close Ties" @default.
- W1566641143 cites W1529124688 @default.
- W1566641143 cites W1539140405 @default.
- W1566641143 cites W1565404221 @default.
- W1566641143 cites W1705747559 @default.
- W1566641143 cites W172002323 @default.
- W1566641143 cites W1820228121 @default.
- W1566641143 cites W1843900867 @default.
- W1566641143 cites W1926115347 @default.
- W1566641143 cites W1936633632 @default.
- W1566641143 cites W1974470246 @default.
- W1566641143 cites W1974547730 @default.
- W1566641143 cites W1975825361 @default.
- W1566641143 cites W1976846310 @default.
- W1566641143 cites W1976957743 @default.
- W1566641143 cites W1977255237 @default.
- W1566641143 cites W1977870976 @default.
- W1566641143 cites W1980986010 @default.
- W1566641143 cites W1981218555 @default.
- W1566641143 cites W1984242978 @default.
- W1566641143 cites W1987910229 @default.
- W1566641143 cites W1990781364 @default.
- W1566641143 cites W1993611116 @default.
- W1566641143 cites W1993917627 @default.
- W1566641143 cites W1994823455 @default.
- W1566641143 cites W1997508587 @default.
- W1566641143 cites W1997686829 @default.
- W1566641143 cites W1997772553 @default.
- W1566641143 cites W1999719776 @default.
- W1566641143 cites W2006048152 @default.
- W1566641143 cites W2009412340 @default.
- W1566641143 cites W2010124801 @default.
- W1566641143 cites W2011766130 @default.
- W1566641143 cites W2013184426 @default.
- W1566641143 cites W2017945794 @default.
- W1566641143 cites W2019582558 @default.
- W1566641143 cites W2020541240 @default.
- W1566641143 cites W2022487205 @default.
- W1566641143 cites W2022498894 @default.
- W1566641143 cites W2023324665 @default.
- W1566641143 cites W2024916097 @default.
- W1566641143 cites W2026756770 @default.
- W1566641143 cites W2035340393 @default.
- W1566641143 cites W2036227669 @default.
- W1566641143 cites W2040603894 @default.
- W1566641143 cites W2041168550 @default.
- W1566641143 cites W2042611146 @default.
- W1566641143 cites W2042932723 @default.
- W1566641143 cites W2043202192 @default.
- W1566641143 cites W2043251964 @default.
- W1566641143 cites W2044240082 @default.
- W1566641143 cites W2045907249 @default.
- W1566641143 cites W2047208611 @default.
- W1566641143 cites W2047284298 @default.
- W1566641143 cites W2047834873 @default.
- W1566641143 cites W2049097764 @default.
- W1566641143 cites W2052009804 @default.
- W1566641143 cites W2053079324 @default.
- W1566641143 cites W2053648508 @default.
- W1566641143 cites W2054368198 @default.
- W1566641143 cites W2054996413 @default.
- W1566641143 cites W2057868246 @default.
- W1566641143 cites W2059282244 @default.
- W1566641143 cites W2059307651 @default.
- W1566641143 cites W2062291205 @default.
- W1566641143 cites W2065363098 @default.
- W1566641143 cites W2066314626 @default.
- W1566641143 cites W2067475521 @default.
- W1566641143 cites W2068382528 @default.
- W1566641143 cites W2073757540 @default.
- W1566641143 cites W2075422139 @default.
- W1566641143 cites W2076426646 @default.
- W1566641143 cites W2080908190 @default.
- W1566641143 cites W2082910152 @default.
- W1566641143 cites W2083700023 @default.
- W1566641143 cites W2083845818 @default.
- W1566641143 cites W2084470407 @default.
- W1566641143 cites W2085397620 @default.
- W1566641143 cites W2088701149 @default.
- W1566641143 cites W2092670603 @default.
- W1566641143 cites W2093355627 @default.
- W1566641143 cites W2096550707 @default.
- W1566641143 cites W2101171643 @default.
- W1566641143 cites W2101928629 @default.
- W1566641143 cites W2104593676 @default.
- W1566641143 cites W2105083335 @default.
- W1566641143 cites W2106025049 @default.
- W1566641143 cites W2107634984 @default.
- W1566641143 cites W2108626793 @default.
- W1566641143 cites W2110957605 @default.
- W1566641143 cites W2112052090 @default.