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- W1566642142 abstract "Summary Nitrogen fixation by the free‐living organism Azotobacter vinelandii can occur through the activity of three different systems that are genetically distinct but mechanistically related. A combination of bioinformatic and biochemical‐genetic studies has revealed that at least 82 different genes are likely to be associated with the formation and regulation of these systems. Studies performed over many years have established that cross‐talk occurs between the various nitrogen fixation systems, and that expression and fine‐tuning of their activities are integrated with overall cellular physiology. Martinez‐Noel and co‐workers now report another newly discovered aspect of the process. Evidence is presented to suggest that a nitrogen fixation‐specific paralogue of ClpX is used to control the accumulation of proteins involved in formation of a metal–sulphur cluster that provides a nitrogenase active site. The intriguing aspect of this work is that it indicates that the nitrogen fixation‐associated ClpX must recruit ClpP, for which a paralogue is not duplicated within any of the nitrogen fixation regions of the genome, to achieve its function related to nitrogen fixation. Inspection of the A. vinelandii genome indicates that such recruitment of cellular housekeeping components is a common feature used to integrate nitrogen fixation with global cellular physiology." @default.
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- W1566642142 date "2011-01-25" @default.
- W1566642142 modified "2023-10-16" @default.
- W1566642142 title "Co-ordination and fine-tuning of nitrogen fixation in Azotobacter vinelandii" @default.
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- W1566642142 doi "https://doi.org/10.1111/j.1365-2958.2011.07541.x" @default.
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