FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566677070> ?p ?o ?g. }

• W1566677070 abstract "The immune system must overcome daily challenges from pathogens to protect the body from infection. The success of the immune response to infection relies on the ability to sense and evaluate microbial threats and coordinate their elimination all the while limiting damage to host tissues. This delicate balance is achieved through coordinated action of innate and adaptive arms of the immune system. The main distinguishing characteristic of these two branches of the immune response is the way they recognize antigens. Whereas innate immunity relies on germline-encoded receptors to sense the presence of pathogens, adaptive immunity employs a highly diverse set of receptors generated through somatic mutation and recombination that are tailored to specific pathogens. The second major defining characteristic of the adaptive immune system is the development of immunological memory that manifests with increased functionality and frequency of responding cells upon re-exposure to the same antigen. Several immune cell subsets play a critical role in mediating innate immune responses. These include neutrophils, natural killer (NK) cells, dendritic cells (DC), and macrophages. These cells are alerted to the presence of pathogens via recognition of microbial non-self, missing self, or altered self (Medzhitov and Janeway 2002). Recognition of microbial entities relies on the detection of conserved molecular patterns referred to as pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) of the innate immune system. The three best-characterized families of PRRs are the toll-like receptors (TLR), the NOD-Like Receptors (NLR) and the retinoic acid-inducible gene (RIG-I)-like RNA helicases (RLHs). Following PAMP encounter, these receptors initiate signaling cascades that drive production of several anti-microbial molecules that ultimately limit pathogen replication and spread. Furthermore innate immune cells activate the adaptive arm of the immune system through the action of soluble mediators and antigen processing and presentation (Kabelitz and Medzhitov 2007; Medzhitov 2007). DCs can be divided into myeloid (mDC) also known as conventional DCs and plasmacytoid DCs (pDCs) (Sallusto and Lanzavecchia 1994; Olweus, BitMansour et al." @default.
• W1566677070 created "2016-06-24" @default.
• W1566677070 creator A5054063341 @default.
• W1566677070 creator A5081176712 @default.
• W1566677070 creator A5090682867 @default.
• W1566677070 date "2012-01-27" @default.
• W1566677070 modified "2023-10-04" @default.
• W1566677070 title "Modulation of Immune Senescence by Menopause and Hormone Therapy" @default.
• W1566677070 cites W1512900561 @default.
• W1566677070 cites W1517310071 @default.
• W1566677070 cites W1531742112 @default.
• W1566677070 cites W1533026006 @default.
• W1566677070 cites W1535236030 @default.
• W1566677070 cites W1538293535 @default.
• W1566677070 cites W1543098232 @default.
• W1566677070 cites W1548058762 @default.
• W1566677070 cites W1556334181 @default.
• W1566677070 cites W155810853 @default.
• W1566677070 cites W1576064052 @default.
• W1566677070 cites W1581000856 @default.
• W1566677070 cites W1586529568 @default.
• W1566677070 cites W1594488493 @default.
• W1566677070 cites W1648002874 @default.
• W1566677070 cites W1773961151 @default.
• W1566677070 cites W1864379337 @default.
• W1566677070 cites W1891697154 @default.
• W1566677070 cites W1893224725 @default.
• W1566677070 cites W1908861496 @default.
• W1566677070 cites W1913017099 @default.
• W1566677070 cites W1916529790 @default.
• W1566677070 cites W1920486352 @default.
• W1566677070 cites W1929781713 @default.
• W1566677070 cites W1932344540 @default.
• W1566677070 cites W1937331953 @default.
• W1566677070 cites W1939125543 @default.
• W1566677070 cites W1940713438 @default.
• W1566677070 cites W1945859829 @default.
• W1566677070 cites W1949149840 @default.
• W1566677070 cites W1964077677 @default.
• W1566677070 cites W1964138458 @default.
• W1566677070 cites W1964467928 @default.
• W1566677070 cites W1964702153 @default.
• W1566677070 cites W1964967659 @default.
• W1566677070 cites W1965213354 @default.
• W1566677070 cites W1966358283 @default.
• W1566677070 cites W19663806 @default.
• W1566677070 cites W1966937220 @default.
• W1566677070 cites W1967020365 @default.
• W1566677070 cites W1967131603 @default.
• W1566677070 cites W1968198282 @default.
• W1566677070 cites W1969341234 @default.
• W1566677070 cites W1969950463 @default.
• W1566677070 cites W1970140452 @default.
• W1566677070 cites W1970261720 @default.
• W1566677070 cites W1970937149 @default.
• W1566677070 cites W1971541149 @default.
• W1566677070 cites W1973426981 @default.
• W1566677070 cites W1973648890 @default.
• W1566677070 cites W1974957492 @default.
• W1566677070 cites W1976594344 @default.
• W1566677070 cites W1976882825 @default.
• W1566677070 cites W1977773205 @default.
• W1566677070 cites W1984015030 @default.
• W1566677070 cites W1986509940 @default.
• W1566677070 cites W1986516189 @default.
• W1566677070 cites W1988758912 @default.
• W1566677070 cites W1990826584 @default.
• W1566677070 cites W1991941102 @default.
• W1566677070 cites W1993094191 @default.
• W1566677070 cites W1993472421 @default.
• W1566677070 cites W1993818414 @default.
• W1566677070 cites W1995780952 @default.
• W1566677070 cites W1996345364 @default.
• W1566677070 cites W1997801508 @default.
• W1566677070 cites W1998935329 @default.
• W1566677070 cites W1999298001 @default.
• W1566677070 cites W2000086683 @default.
• W1566677070 cites W2001320571 @default.
• W1566677070 cites W2001707914 @default.
• W1566677070 cites W2002225831 @default.
• W1566677070 cites W2002624163 @default.
• W1566677070 cites W2003414972 @default.
• W1566677070 cites W2006317112 @default.
• W1566677070 cites W2006772331 @default.
• W1566677070 cites W2007809342 @default.
• W1566677070 cites W2008243630 @default.
• W1566677070 cites W2008483698 @default.
• W1566677070 cites W2010136315 @default.
• W1566677070 cites W2010559487 @default.
• W1566677070 cites W2011350103 @default.
• W1566677070 cites W2013273227 @default.
• W1566677070 cites W2014297054 @default.
• W1566677070 cites W2014324389 @default.
• W1566677070 cites W2014379347 @default.
• W1566677070 cites W2018746957 @default.
• W1566677070 cites W2019840235 @default.
• W1566677070 cites W2020376530 @default.
• W1566677070 cites W2020931454 @default.
• W1566677070 cites W2024169001 @default.
• W1566677070 cites W2024896474 @default.

• next