FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566679959> ?p ?o ?g. }

• W1566679959 abstract "Like other neurodegenerative diseases, Alzheimer Disease (AD) has a prominent inflammatory component mediated by brain microglia. Reducing microglial inflammation could potentially halt or at least slow the neurodegenerative process. A major challenge in the development of treatments targeting brain inflammation is the sheer complexity of the molecular mechanisms that determine whether microglia become inflammatory or take on a more neuroprotective phenotype. The process is highly multifactorial, raising the possibility that a multi-target/multi-drug strategy could be more effective than conventional monotherapy. This study takes a computational approach in finding combinations of approved drugs that are potentially more effective than single drugs in reducing microglial inflammation in AD. This novel approach exploits the distinct advantages of two different computer programming languages, one imperative and the other declarative. Existing programs written in both languages implement the same model of microglial behavior, and the input/output relationships of both programs agree with each other and with data on microglia over an extensive test battery. Here the imperative program is used efficiently to screen the model for the most efficacious combinations of 10 drugs, while the declarative program is used to analyze in detail the mechanisms of action of the most efficacious combinations. Of the 1024 possible drug combinations, the simulated screen identifies only 7 that are able to move simulated microglia at least 50% of the way from a neurotoxic to a neuroprotective phenotype. Subsequent analysis shows that of the 7 most efficacious combinations, 2 stand out as superior both in strength and reliability. The model offers many experimentally testable and therapeutically relevant predictions concerning effective drug combinations and their mechanisms of action." @default.
• W1566679959 created "2016-06-24" @default.
• W1566679959 creator A5082504203 @default.
• W1566679959 date "2015-06-05" @default.
• W1566679959 modified "2023-09-27" @default.
• W1566679959 title "Computational identification of potential multi-drug combinations for reduction of microglial inflammation in Alzheimer disease" @default.
• W1566679959 cites W132449613 @default.
• W1566679959 cites W1527636392 @default.
• W1566679959 cites W1592483428 @default.
• W1566679959 cites W1678111194 @default.
• W1566679959 cites W1684311634 @default.
• W1566679959 cites W1955724354 @default.
• W1566679959 cites W1964229968 @default.
• W1566679959 cites W1968544465 @default.
• W1566679959 cites W1972519999 @default.
• W1566679959 cites W1974966491 @default.
• W1566679959 cites W1980629288 @default.
• W1566679959 cites W1986397618 @default.
• W1566679959 cites W1994326835 @default.
• W1566679959 cites W2001349268 @default.
• W1566679959 cites W2009901431 @default.
• W1566679959 cites W2024816116 @default.
• W1566679959 cites W2033591223 @default.
• W1566679959 cites W2036409697 @default.
• W1566679959 cites W2041464039 @default.
• W1566679959 cites W2044025814 @default.
• W1566679959 cites W2045417011 @default.
• W1566679959 cites W2047717012 @default.
• W1566679959 cites W2048437011 @default.
• W1566679959 cites W2048510554 @default.
• W1566679959 cites W2054531769 @default.
• W1566679959 cites W2057366744 @default.
• W1566679959 cites W2063265278 @default.
• W1566679959 cites W2065678033 @default.
• W1566679959 cites W2067267561 @default.
• W1566679959 cites W2067443877 @default.
• W1566679959 cites W2073424829 @default.
• W1566679959 cites W2082429191 @default.
• W1566679959 cites W2095462726 @default.
• W1566679959 cites W2096410114 @default.
• W1566679959 cites W2098682735 @default.
• W1566679959 cites W2107690867 @default.
• W1566679959 cites W2108163830 @default.
• W1566679959 cites W2108597252 @default.
• W1566679959 cites W2112880160 @default.
• W1566679959 cites W2113107925 @default.
• W1566679959 cites W2115855931 @default.
• W1566679959 cites W2125912583 @default.
• W1566679959 cites W2127934565 @default.
• W1566679959 cites W2128007601 @default.
• W1566679959 cites W2128533924 @default.
• W1566679959 cites W2130145174 @default.
• W1566679959 cites W2140131793 @default.
• W1566679959 cites W2153767933 @default.
• W1566679959 cites W2155347072 @default.
• W1566679959 cites W2156019676 @default.
• W1566679959 cites W2158676848 @default.
• W1566679959 cites W2159027833 @default.
• W1566679959 cites W2160527918 @default.
• W1566679959 cites W2165152500 @default.
• W1566679959 cites W2169815691 @default.
• W1566679959 cites W2171775027 @default.
• W1566679959 cites W2291628530 @default.
• W1566679959 cites W2330539082 @default.
• W1566679959 cites W4238596965 @default.
• W1566679959 cites W4251228600 @default.
• W1566679959 doi "https://doi.org/10.3389/fphar.2015.00116" @default.
• W1566679959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4456568" @default.
• W1566679959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26097457" @default.
• W1566679959 hasPublicationYear "2015" @default.
• W1566679959 type Work @default.
• W1566679959 sameAs 1566679959 @default.
• W1566679959 citedByCount "22" @default.
• W1566679959 countsByYear W15666799592015 @default.
• W1566679959 countsByYear W15666799592016 @default.
• W1566679959 countsByYear W15666799592017 @default.
• W1566679959 countsByYear W15666799592018 @default.
• W1566679959 countsByYear W15666799592019 @default.
• W1566679959 countsByYear W15666799592020 @default.
• W1566679959 countsByYear W15666799592021 @default.
• W1566679959 countsByYear W15666799592022 @default.
• W1566679959 crossrefType "journal-article" @default.
• W1566679959 hasAuthorship W1566679959A5082504203 @default.
• W1566679959 hasBestOaLocation W15666799591 @default.
• W1566679959 hasConcept C142724271 @default.
• W1566679959 hasConcept C169760540 @default.
• W1566679959 hasConcept C203014093 @default.
• W1566679959 hasConcept C25498285 @default.
• W1566679959 hasConcept C2776914184 @default.
• W1566679959 hasConcept C2779134260 @default.
• W1566679959 hasConcept C2779830541 @default.
• W1566679959 hasConcept C2780035454 @default.
• W1566679959 hasConcept C41008148 @default.
• W1566679959 hasConcept C60644358 @default.
• W1566679959 hasConcept C71924100 @default.
• W1566679959 hasConcept C74187038 @default.
• W1566679959 hasConcept C86803240 @default.
• W1566679959 hasConcept C98274493 @default.
• W1566679959 hasConceptScore W1566679959C142724271 @default.
• W1566679959 hasConceptScore W1566679959C169760540 @default.

• next