FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566690127> ?p ?o ?g. }

• W1566690127 abstract "FDA approval of new therapies in 2011 has greatly expanded the treatment options for metastatic melanoma. Patients with V600 mutant v-raf murine sarcoma viral oncogene homolog B1 (B-RAF) positive metastatic melanoma are now treated with the RAF inhibitor, vemurafenib (Zelboraf) as a first line therapy. Vemurafenib decreases tumor size by at least 30% in approximately 50% of patients and increases progression-free survival and overall patient survival compared to the previous standard-of-care, dacarbazine. However, some patients treated with vemurafenib fail to show significant tumor shrinkage, and most patients who initially respond to the drug eventually show disease progression. Therefore, there is a clinical need to improve efficacy and prevent resistance to vemurafenib. It has been previously shown that cell death resulting from RAF/mitogen-activated protein kinase kinase (MEK) inhibition is largely dependent on increased expression of pro-apoptotic, Bcl-2 homology domain (BH3)-only proteins, such as Bcl-2-like 11 (Bim-EL) and Bcl-2 modifying factor (Bmf). Here, we show that contrary to expression of Bim-EL and Bmf, the pro-apoptotic, BH3-only protein, phorbol-12-myristate-13-acetate-induced protein 1 (Noxa), is strongly downregulated after RAF/MEK inhibition. This downregulation occurs at both the protein and mRNA level of expression and is associated with the inhibition of cell cycle progression. Restoring expression of Noxa in combination with RAF/MEK inhibition enhances cell death. Co-expression of the pro-survival, B-cell CLL/lymphoma 2 (Bcl-2) family member, myeloid cell leukemia sequence 1 (Mcl-1), with Noxa fully mitigates the enhanced cell death associated with increased Noxa expression. These data indicate that manipulating the Noxa/Mcl-1 axis may enhance the efficacy of RAF/MEK inhibitors." @default.
• W1566690127 created "2016-06-24" @default.
• W1566690127 creator A5016616108 @default.
• W1566690127 creator A5033787308 @default.
• W1566690127 date "2012-01-01" @default.
• W1566690127 modified "2023-10-03" @default.
• W1566690127 title "Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells." @default.
• W1566690127 cites W1509340652 @default.
• W1566690127 cites W1982972087 @default.
• W1566690127 cites W1984547206 @default.
• W1566690127 cites W1985111376 @default.
• W1566690127 cites W1990376228 @default.
• W1566690127 cites W1990408342 @default.
• W1566690127 cites W2003130292 @default.
• W1566690127 cites W2003753849 @default.
• W1566690127 cites W2009642188 @default.
• W1566690127 cites W2014250484 @default.
• W1566690127 cites W2015680924 @default.
• W1566690127 cites W2017187984 @default.
• W1566690127 cites W2027395744 @default.
• W1566690127 cites W2031858847 @default.
• W1566690127 cites W2032211985 @default.
• W1566690127 cites W2032941109 @default.
• W1566690127 cites W2033089897 @default.
• W1566690127 cites W2043058822 @default.
• W1566690127 cites W2050984994 @default.
• W1566690127 cites W2080686146 @default.
• W1566690127 cites W2085419794 @default.
• W1566690127 cites W2097995306 @default.
• W1566690127 cites W2100614336 @default.
• W1566690127 cites W2106391833 @default.
• W1566690127 cites W2106543129 @default.
• W1566690127 cites W2112396699 @default.
• W1566690127 cites W2127474966 @default.
• W1566690127 cites W2128542677 @default.
• W1566690127 cites W2134802480 @default.
• W1566690127 cites W2141674733 @default.
• W1566690127 cites W2163188200 @default.
• W1566690127 cites W2168143310 @default.
• W1566690127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3512187" @default.
• W1566690127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23226618" @default.
• W1566690127 hasPublicationYear "2012" @default.
• W1566690127 type Work @default.
• W1566690127 sameAs 1566690127 @default.
• W1566690127 citedByCount "6" @default.
• W1566690127 countsByYear W15666901272015 @default.
• W1566690127 countsByYear W15666901272016 @default.
• W1566690127 countsByYear W15666901272017 @default.
• W1566690127 countsByYear W15666901272023 @default.
• W1566690127 crossrefType "journal-article" @default.
• W1566690127 hasAuthorship W1566690127A5016616108 @default.
• W1566690127 hasAuthorship W1566690127A5033787308 @default.
• W1566690127 hasConcept C104317684 @default.
• W1566690127 hasConcept C127561419 @default.
• W1566690127 hasConcept C184235292 @default.
• W1566690127 hasConcept C190283241 @default.
• W1566690127 hasConcept C2776131300 @default.
• W1566690127 hasConcept C2777658100 @default.
• W1566690127 hasConcept C2780964509 @default.
• W1566690127 hasConcept C2994587330 @default.
• W1566690127 hasConcept C31573885 @default.
• W1566690127 hasConcept C502942594 @default.
• W1566690127 hasConcept C55493867 @default.
• W1566690127 hasConcept C57074206 @default.
• W1566690127 hasConcept C71924100 @default.
• W1566690127 hasConcept C86803240 @default.
• W1566690127 hasConcept C95444343 @default.
• W1566690127 hasConcept C97029542 @default.
• W1566690127 hasConceptScore W1566690127C104317684 @default.
• W1566690127 hasConceptScore W1566690127C127561419 @default.
• W1566690127 hasConceptScore W1566690127C184235292 @default.
• W1566690127 hasConceptScore W1566690127C190283241 @default.
• W1566690127 hasConceptScore W1566690127C2776131300 @default.
• W1566690127 hasConceptScore W1566690127C2777658100 @default.
• W1566690127 hasConceptScore W1566690127C2780964509 @default.
• W1566690127 hasConceptScore W1566690127C2994587330 @default.
• W1566690127 hasConceptScore W1566690127C31573885 @default.
• W1566690127 hasConceptScore W1566690127C502942594 @default.
• W1566690127 hasConceptScore W1566690127C55493867 @default.
• W1566690127 hasConceptScore W1566690127C57074206 @default.
• W1566690127 hasConceptScore W1566690127C71924100 @default.
• W1566690127 hasConceptScore W1566690127C86803240 @default.
• W1566690127 hasConceptScore W1566690127C95444343 @default.
• W1566690127 hasConceptScore W1566690127C97029542 @default.
• W1566690127 hasLocation W15666901271 @default.
• W1566690127 hasOpenAccess W1566690127 @default.
• W1566690127 hasPrimaryLocation W15666901271 @default.
• W1566690127 hasRelatedWork W2032211985 @default.
• W1566690127 hasRelatedWork W2041052361 @default.
• W1566690127 hasRelatedWork W2043058822 @default.
• W1566690127 hasRelatedWork W2045097765 @default.
• W1566690127 hasRelatedWork W2099604307 @default.
• W1566690127 hasRelatedWork W2102338067 @default.
• W1566690127 hasRelatedWork W2128542677 @default.
• W1566690127 hasRelatedWork W2145482514 @default.
• W1566690127 hasRelatedWork W2163188200 @default.
• W1566690127 hasRelatedWork W2167334545 @default.
• W1566690127 hasRelatedWork W2315978372 @default.
• W1566690127 hasRelatedWork W2330999209 @default.
• W1566690127 hasRelatedWork W2398682911 @default.

• next