FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566705082> ?p ?o ?g. }

• W1566705082 abstract "Adult T-cell leukemia/lymphoma (ATLL) caused by the retrovirus human T-cell leukemia virus type 1 (HTLV-1) infection is one of aggressive mature CD4+ T-cell neoplasms with a marked expansion of leukemic cells during the acute phase. ATLL is endemic in several regions of the world, especially in southwest Japan, the Caribbean basin, and parts of Central Africa. ATLL is divided into four clinical subtypes: acute, chronic, smoldering, and lymphoma type, based on the number of leukemic cells in peripheral blood, serum lactic acid dehydrogenase level, tumor lesions in various organs, and clinical course. The acute and lymphoma types still have an extremely poor prognosis, despite the advance in chemotherapy. Chemotherapy for ATLL has limited efficacy with median survivals of approximate one year. The HTLV-1 genome encodes not only structural proteins, but also non-structural proteins such as Tax, Rex, p13, p12, p30, p21Rex and HTLV-1 bZIP factor (HBZ). The functional analysis of the viral proteins such as Tax has shed light on the pathogenesis of ATLL. Tax is a crucial viral protein encoded by the pX region, which can induce viral replication and a variety of cellular genes associated with cytokine production, inhibition of apoptosis and cell cycle dysregulation (Arima 1999, Azimi 1998, Geleziunas 1998, Kanno 1994, Mori 1996b). Tax-induced gene regulation, which is linked to malignant transformation of HTLV-1-infected T-cells, has been shown to be mediated by CREB/ATF, NF-B and SRF pathways. Constitutive activation of NF-B is one of common features of HTLV-1–transformed T-cells and ATLL leukemic cells, since inhibition of NF-B activity reduces cell growth and induces apoptosis of cells, suggesting a central role of NF-B in their proliferation and survival. Moreover, Tax binds to the upstream kinase, the mitogen-activated protein kinase/ERK kinase kinase-1 and enhance its kinase activity (Harhaj 1999, Huang 2002, Jin 1999). Nevertheless, ATLL develops in a period 40 to 60 years after initial infection, indicating that the development of ATLL requires a multistep oncogenic process including accumulation of genetic mutations. HTLV-1 infection alone is not sufficient to induce neoplastic transformation of infected cells. In fact, viral gene expression is at extremely low levels in primary ATLL cells (Franchini 1984). Thus, the mechanism which develops ATLL still remains unclear." @default.
• W1566705082 created "2016-06-24" @default.
• W1566705082 creator A5013259135 @default.
• W1566705082 creator A5021889272 @default.
• W1566705082 creator A5035925768 @default.
• W1566705082 creator A5056086946 @default.
• W1566705082 creator A5085575381 @default.
• W1566705082 date "2011-10-26" @default.
• W1566705082 modified "2023-09-25" @default.
• W1566705082 title "Constitutive Activation of the JAK/STAT and Toll-Like Receptor Signaling Pathways in Adult T-Cell Leukemia/Lymphoma" @default.
• W1566705082 cites W119871615 @default.
• W1566705082 cites W1505999155 @default.
• W1566705082 cites W159302622 @default.
• W1566705082 cites W1606216715 @default.
• W1566705082 cites W1607664081 @default.
• W1566705082 cites W1655860314 @default.
• W1566705082 cites W166636401 @default.
• W1566705082 cites W166740373 @default.
• W1566705082 cites W1684997688 @default.
• W1566705082 cites W168754456 @default.
• W1566705082 cites W1770811198 @default.
• W1566705082 cites W179818011 @default.
• W1566705082 cites W1950448919 @default.
• W1566705082 cites W195552824 @default.
• W1566705082 cites W1958363133 @default.
• W1566705082 cites W1964531685 @default.
• W1566705082 cites W1965530957 @default.
• W1566705082 cites W1967960991 @default.
• W1566705082 cites W1969058122 @default.
• W1566705082 cites W1969090908 @default.
• W1566705082 cites W1969218281 @default.
• W1566705082 cites W1978019581 @default.
• W1566705082 cites W1978434703 @default.
• W1566705082 cites W1982210847 @default.
• W1566705082 cites W1986527340 @default.
• W1566705082 cites W1995495460 @default.
• W1566705082 cites W1997715052 @default.
• W1566705082 cites W1998585620 @default.
• W1566705082 cites W1999804934 @default.
• W1566705082 cites W2000222996 @default.
• W1566705082 cites W2001192978 @default.
• W1566705082 cites W2006488152 @default.
• W1566705082 cites W2012615147 @default.
• W1566705082 cites W2012628280 @default.
• W1566705082 cites W2013691481 @default.
• W1566705082 cites W2016590458 @default.
• W1566705082 cites W2020314417 @default.
• W1566705082 cites W2022215206 @default.
• W1566705082 cites W2023720312 @default.
• W1566705082 cites W2024282024 @default.
• W1566705082 cites W2029312116 @default.
• W1566705082 cites W2030411429 @default.
• W1566705082 cites W2037368492 @default.
• W1566705082 cites W2038181085 @default.
• W1566705082 cites W2039124116 @default.
• W1566705082 cites W2039713566 @default.
• W1566705082 cites W2043150114 @default.
• W1566705082 cites W2044268362 @default.
• W1566705082 cites W2051705414 @default.
• W1566705082 cites W2056106902 @default.
• W1566705082 cites W2058227448 @default.
• W1566705082 cites W2060019843 @default.
• W1566705082 cites W2062892166 @default.
• W1566705082 cites W2063128111 @default.
• W1566705082 cites W2064021511 @default.
• W1566705082 cites W2068211039 @default.
• W1566705082 cites W2070242833 @default.
• W1566705082 cites W2071798710 @default.
• W1566705082 cites W2074356752 @default.
• W1566705082 cites W2074571739 @default.
• W1566705082 cites W2074959305 @default.
• W1566705082 cites W2079011320 @default.
• W1566705082 cites W2079126872 @default.
• W1566705082 cites W2081080474 @default.
• W1566705082 cites W2082964839 @default.
• W1566705082 cites W2083802827 @default.
• W1566705082 cites W2084381488 @default.
• W1566705082 cites W2088162695 @default.
• W1566705082 cites W2089904066 @default.
• W1566705082 cites W2090498735 @default.
• W1566705082 cites W2093973061 @default.
• W1566705082 cites W2094892715 @default.
• W1566705082 cites W2097045568 @default.
• W1566705082 cites W2097765112 @default.
• W1566705082 cites W2101363646 @default.
• W1566705082 cites W2108889221 @default.
• W1566705082 cites W2110807341 @default.
• W1566705082 cites W2110826114 @default.
• W1566705082 cites W2116101489 @default.
• W1566705082 cites W2116382435 @default.
• W1566705082 cites W2116641130 @default.
• W1566705082 cites W2118318403 @default.
• W1566705082 cites W2119275893 @default.
• W1566705082 cites W2122275228 @default.
• W1566705082 cites W2130003099 @default.
• W1566705082 cites W2130982757 @default.
• W1566705082 cites W2131666890 @default.
• W1566705082 cites W2133727636 @default.
• W1566705082 cites W2134582745 @default.
• W1566705082 cites W2140795762 @default.

• next