Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566718798> ?p ?o ?g. }
- W1566718798 endingPage "2824" @default.
- W1566718798 startingPage "2814" @default.
- W1566718798 abstract "Abstract The EBV-induced gene 3 (EBI3) is expressed in dendritic cells (DCs) and part of the cytokine IL-27 that controls Th cell development. However, its regulated expression in DCs is poorly understood. In the present study we demonstrate that EBI3 is expressed in splenic CD8−, CD8+, and plasmacytoid DC subsets and is induced upon TLR signaling. Cloning and functional analysis of the EBI3 promoter using in vivo footprinting and mutagenesis showed that stimulation via TLR2, TLR4, and TLR9 transactivated the promoter in primary DCs via NF-κB and Ets binding sites at −90 and −73 bp upstream of the transcriptional start site, respectively. Furthermore, we observed that NF-κB p50/p65 and PU.1 were sufficient to transactivate the EBI3 promoter in EBI3-deficient 293 cells. Finally, induced EBI3 gene expression in DCs was reduced or abrogated in TLR-2/TLR4, TLR9, and MyD88 knockout mice, whereas both basal and inducible EBI3 mRNA levels in DCs were strongly suppressed in NF-κB p50-deficient mice. In summary, these data suggest that EBI3 expression in DCs is transcriptionally regulated by TLR signaling via MyD88 and NF-κB. Thus, EBI3 gene transcription in DCs is induced rapidly by TLR signaling during innate immune responses preceding cytokine driven Th cell development." @default.
- W1566718798 created "2016-06-24" @default.
- W1566718798 creator A5003042131 @default.
- W1566718798 creator A5008057406 @default.
- W1566718798 creator A5012646641 @default.
- W1566718798 creator A5015377299 @default.
- W1566718798 creator A5032480207 @default.
- W1566718798 creator A5050382610 @default.
- W1566718798 creator A5054599656 @default.
- W1566718798 creator A5066374648 @default.
- W1566718798 creator A5085131013 @default.
- W1566718798 creator A5085857476 @default.
- W1566718798 date "2005-03-01" @default.
- W1566718798 modified "2023-10-01" @default.
- W1566718798 title "EBV-Induced Gene 3 Transcription Is Induced by TLR Signaling in Primary Dendritic Cells via NF-κB Activation" @default.
- W1566718798 cites W1501402501 @default.
- W1566718798 cites W1514540900 @default.
- W1566718798 cites W1522580416 @default.
- W1566718798 cites W1555985183 @default.
- W1566718798 cites W1558372199 @default.
- W1566718798 cites W1710688418 @default.
- W1566718798 cites W1947436130 @default.
- W1566718798 cites W1966892322 @default.
- W1566718798 cites W1967261754 @default.
- W1566718798 cites W1982637996 @default.
- W1566718798 cites W1986370046 @default.
- W1566718798 cites W1995808454 @default.
- W1566718798 cites W1996120614 @default.
- W1566718798 cites W2001487156 @default.
- W1566718798 cites W2001617137 @default.
- W1566718798 cites W2003182569 @default.
- W1566718798 cites W2009219530 @default.
- W1566718798 cites W2016956768 @default.
- W1566718798 cites W2035616122 @default.
- W1566718798 cites W2047054188 @default.
- W1566718798 cites W2048267618 @default.
- W1566718798 cites W2051662558 @default.
- W1566718798 cites W2057505571 @default.
- W1566718798 cites W2057522151 @default.
- W1566718798 cites W2073242835 @default.
- W1566718798 cites W2075742711 @default.
- W1566718798 cites W2076889715 @default.
- W1566718798 cites W2085525483 @default.
- W1566718798 cites W2087905758 @default.
- W1566718798 cites W2092235636 @default.
- W1566718798 cites W2107933989 @default.
- W1566718798 cites W2110051910 @default.
- W1566718798 cites W2111980183 @default.
- W1566718798 cites W2119986617 @default.
- W1566718798 cites W2129292145 @default.
- W1566718798 cites W2129319296 @default.
- W1566718798 cites W2138961639 @default.
- W1566718798 cites W2142446767 @default.
- W1566718798 cites W2144515939 @default.
- W1566718798 cites W2146298020 @default.
- W1566718798 cites W2150564865 @default.
- W1566718798 cites W2159546356 @default.
- W1566718798 cites W2166695274 @default.
- W1566718798 cites W2168581900 @default.
- W1566718798 cites W2170944561 @default.
- W1566718798 cites W249403745 @default.
- W1566718798 cites W96350623 @default.
- W1566718798 doi "https://doi.org/10.4049/jimmunol.174.5.2814" @default.
- W1566718798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15728491" @default.
- W1566718798 hasPublicationYear "2005" @default.
- W1566718798 type Work @default.
- W1566718798 sameAs 1566718798 @default.
- W1566718798 citedByCount "147" @default.
- W1566718798 countsByYear W15667187982012 @default.
- W1566718798 countsByYear W15667187982013 @default.
- W1566718798 countsByYear W15667187982014 @default.
- W1566718798 countsByYear W15667187982015 @default.
- W1566718798 countsByYear W15667187982016 @default.
- W1566718798 countsByYear W15667187982017 @default.
- W1566718798 countsByYear W15667187982018 @default.
- W1566718798 countsByYear W15667187982019 @default.
- W1566718798 countsByYear W15667187982020 @default.
- W1566718798 countsByYear W15667187982021 @default.
- W1566718798 countsByYear W15667187982022 @default.
- W1566718798 countsByYear W15667187982023 @default.
- W1566718798 crossrefType "journal-article" @default.
- W1566718798 hasAuthorship W1566718798A5003042131 @default.
- W1566718798 hasAuthorship W1566718798A5008057406 @default.
- W1566718798 hasAuthorship W1566718798A5012646641 @default.
- W1566718798 hasAuthorship W1566718798A5015377299 @default.
- W1566718798 hasAuthorship W1566718798A5032480207 @default.
- W1566718798 hasAuthorship W1566718798A5050382610 @default.
- W1566718798 hasAuthorship W1566718798A5054599656 @default.
- W1566718798 hasAuthorship W1566718798A5066374648 @default.
- W1566718798 hasAuthorship W1566718798A5085131013 @default.
- W1566718798 hasAuthorship W1566718798A5085857476 @default.
- W1566718798 hasBestOaLocation W15667187981 @default.
- W1566718798 hasConcept C104317684 @default.
- W1566718798 hasConcept C136449434 @default.
- W1566718798 hasConcept C150194340 @default.
- W1566718798 hasConcept C153911025 @default.
- W1566718798 hasConcept C190727270 @default.
- W1566718798 hasConcept C203014093 @default.