FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566744867> ?p ?o ?g. }

• W1566744867 endingPage "3714" @default.
• W1566744867 startingPage "3704" @default.
• W1566744867 abstract "A phylogenetic analysis of 52 published and 37 new nucleoprotein (NP) gene sequences addressed the evolution and origin of human and swine influenza A viruses. H1N1 human and classical swine viruses (i.e., those related to Swine/Iowa/15/30) share a single common ancestor, which was estimated to have occurred in 1912 to 1913. From this common ancestor, human and classical swine virus NP genes have evolved at similar rates that are higher than in avian virus NP genes (3.31 to 3.41 versus 1.90 nucleotide changes per year). At the protein level, human virus NPs have evolved twice as fast as classical swine virus NPs (0.66 versus 0.34 amino acid change per year). Despite evidence of frequent interspecies transmission of human and classical swine viruses, our analysis indicates that these viruses have evolved independently since well before the first isolates in the early 1930s. Although our analysis cannot reveal the original host, the ancestor virus was avianlike, showing only five amino acid differences from the root of the avian virus NP lineage. The common pattern of relationship and origin for the NP and other genes of H1N1 human and classical swine viruses suggests that the common ancestor was an avian virus and not a reassortant derived from previous human or swine influenza A viruses. The new avianlike H1N1 swine viruses in Europe may provide a model for the evolution of newly introduced avian viruses into the swine host reservoir. The NPs of these viruses are evolving more rapidly than those of human or classical swine viruses (4.50 nucleotide changes and 0.74 amino acid change per year), and when these rates are applied to pre-1930s human and classical swine virus NPs, the predicted date of a common ancestor is 1918 rather than 1912 to 1913. Thus, our NP phylogeny is consistent with historical records and the proposal that a short time before 1918, a new H1N1 avianlike virus entered human or swine hosts (O. T. Gorman, R. O. Donis, Y. Kawaoka, and R. G. Webster, J. Virol. 64:4893-4902, 1990). This virus provided the ancestors of all known human influenza A virus genes, except for HA, NA, and PB1, which have since been reassorted from avian viruses. We propose that during 1918 a virulent strain of this new avianlike virus caused a severe human influenza pandemic and that the pandemic virus was introduced into North American swine populations, constituting the origin of classical swine virus." @default.
• W1566744867 created "2016-06-24" @default.
• W1566744867 creator A5016442328 @default.
• W1566744867 creator A5029848463 @default.
• W1566744867 creator A5042524524 @default.
• W1566744867 creator A5076363097 @default.
• W1566744867 creator A5081508151 @default.
• W1566744867 creator A5091454011 @default.
• W1566744867 date "1991-07-01" @default.
• W1566744867 modified "2023-09-25" @default.
• W1566744867 title "Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine viruses" @default.
• W1566744867 cites W1541595517 @default.
• W1566744867 cites W1544994312 @default.
• W1566744867 cites W1867125150 @default.
• W1566744867 cites W1882196682 @default.
• W1566744867 cites W1967437727 @default.
• W1566744867 cites W1976500671 @default.
• W1566744867 cites W1985570485 @default.
• W1566744867 cites W1989445422 @default.
• W1566744867 cites W1993745345 @default.
• W1566744867 cites W1998170980 @default.
• W1566744867 cites W2009221439 @default.
• W1566744867 cites W2010638120 @default.
• W1566744867 cites W2015210358 @default.
• W1566744867 cites W2024351097 @default.
• W1566744867 cites W2029918352 @default.
• W1566744867 cites W2031611104 @default.
• W1566744867 cites W2032140599 @default.
• W1566744867 cites W2032542050 @default.
• W1566744867 cites W2036084483 @default.
• W1566744867 cites W2043472514 @default.
• W1566744867 cites W2048002397 @default.
• W1566744867 cites W2060377782 @default.
• W1566744867 cites W2078153134 @default.
• W1566744867 cites W2081480299 @default.
• W1566744867 cites W2081826641 @default.
• W1566744867 cites W2081945723 @default.
• W1566744867 cites W2081949838 @default.
• W1566744867 cites W2083285393 @default.
• W1566744867 cites W2085126545 @default.
• W1566744867 cites W2088399351 @default.
• W1566744867 cites W2089854312 @default.
• W1566744867 cites W2092292942 @default.
• W1566744867 cites W2109157282 @default.
• W1566744867 cites W2111959741 @default.
• W1566744867 cites W2122912808 @default.
• W1566744867 cites W2127004094 @default.
• W1566744867 cites W2127629333 @default.
• W1566744867 cites W2138264857 @default.
• W1566744867 cites W2157583784 @default.
• W1566744867 cites W2160697722 @default.
• W1566744867 cites W2164759261 @default.
• W1566744867 cites W2218740860 @default.
• W1566744867 cites W2266876246 @default.
• W1566744867 cites W2415480667 @default.
• W1566744867 doi "https://doi.org/10.1128/jvi.65.7.3704-3714.1991" @default.
• W1566744867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/241390" @default.
• W1566744867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2041090" @default.
• W1566744867 hasPublicationYear "1991" @default.
• W1566744867 type Work @default.
• W1566744867 sameAs 1566744867 @default.
• W1566744867 citedByCount "194" @default.
• W1566744867 countsByYear W15667448672012 @default.
• W1566744867 countsByYear W15667448672013 @default.
• W1566744867 countsByYear W15667448672014 @default.
• W1566744867 countsByYear W15667448672015 @default.
• W1566744867 countsByYear W15667448672016 @default.
• W1566744867 countsByYear W15667448672017 @default.
• W1566744867 countsByYear W15667448672019 @default.
• W1566744867 countsByYear W15667448672020 @default.
• W1566744867 countsByYear W15667448672021 @default.
• W1566744867 countsByYear W15667448672022 @default.
• W1566744867 countsByYear W15667448672023 @default.
• W1566744867 crossrefType "journal-article" @default.
• W1566744867 hasAuthorship W1566744867A5016442328 @default.
• W1566744867 hasAuthorship W1566744867A5029848463 @default.
• W1566744867 hasAuthorship W1566744867A5042524524 @default.
• W1566744867 hasAuthorship W1566744867A5076363097 @default.
• W1566744867 hasAuthorship W1566744867A5081508151 @default.
• W1566744867 hasAuthorship W1566744867A5091454011 @default.
• W1566744867 hasBestOaLocation W15667448671 @default.
• W1566744867 hasConcept C104317684 @default.
• W1566744867 hasConcept C126831891 @default.
• W1566744867 hasConcept C141231307 @default.
• W1566744867 hasConcept C142724271 @default.
• W1566744867 hasConcept C159047783 @default.
• W1566744867 hasConcept C16154277 @default.
• W1566744867 hasConcept C193252679 @default.
• W1566744867 hasConcept C197583594 @default.
• W1566744867 hasConcept C2522874641 @default.
• W1566744867 hasConcept C2776817793 @default.
• W1566744867 hasConcept C2777546802 @default.
• W1566744867 hasConcept C2779134260 @default.
• W1566744867 hasConcept C3008058167 @default.
• W1566744867 hasConcept C519248777 @default.
• W1566744867 hasConcept C524204448 @default.
• W1566744867 hasConcept C54355233 @default.
• W1566744867 hasConcept C60325843 @default.

• next