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• W1566748787 abstract "A tremendous effort has been and is currently being devoted to the research in the field of pharmaceutical nanotechnology. Several peculiar properties of gelled polymeric nanosize (<1μm) particulate systems have been reported, among which the ability to encapsulate either small molecular weight or macromolecular active principles in mild conditions and protect them from degradation by the harsh pH conditions or enzymes they may encounter in the organism, promote transport of actives across mucosal barriers, undergo internalization by cells thereby carrying actives into them. Chitosan, a copolymer of glucosamine and Nacetylglucosamine, obtained by deacetylation of the naturally-occurring chitin, has been studied as a basic biomaterial for preparing pharmaceutical nanoparticles, because it is biodegradable and has a very low toxicity [1-5] besides an ability to promote transport of drugs, peptides and proteins across mucosal barriers [6-10]. The preparation procedures of chitosan nanoparticles, their characterization for drug encapsulation efficiency, physical and biophar‐ maceutical properties, and toxicity have been covered by recent reviews (11,12). Chitosan has been subjected to derivatization, taking advantage of the reactivity of the primary amino group in position 2, or the hydroxyl group in position 6 of its repeating unit, glucosamine. The derivatization changed the physicochemical, biopharmaceutical and biological properties of the parent chitosan and each derivative type lent itself to preparing nanoparticles with their own physical properties (size, shape, surface charge), drug encapsulation and release capa‐ bility, biopharmaceutical and biological properties (mucoadhesivity, ability to promote drug transport across biological barriers, aptitude for internalization within cells, citotoxicity)." @default.
• W1566748787 created "2016-06-24" @default.
• W1566748787 creator A5064470065 @default.
• W1566748787 date "2013-03-27" @default.
• W1566748787 modified "2023-09-26" @default.
• W1566748787 title "Nanoparticles Based on Chitosan Derivatives" @default.
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• W1566748787 doi "https://doi.org/10.5772/54944" @default.
• W1566748787 hasPublicationYear "2013" @default.
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