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- W1566754413 abstract "Nephrogenic systemic fibrosis (NSF), previously known as nephrogenic fibrosing dermopathy, is a generalized fibrotic disorder occurring in people with renal failure, following exposure to gadolinium-based contrast agents used to enhance MRI. The cellular elements involved in pathology of NSF include bone-marrow-derived collagen-producing fibrocytes, myofibroblasts and activated macrophages. Mechanisms that have been hypothesized to play a role in the pathogenesis of NSF include upregulation of osteopontin, imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinase 1, and presence of transforming growth factor-β, nuclear factor κB, decorin and metallothioneins. Gadolinium (both free and chelated) is thought to be a bioactive trigger for NSF. Elucidation of these potential pathomechanisms would be useful for development of targeted therapies for NSF." @default.
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- W1566754413 date "2011-07-25" @default.
- W1566754413 modified "2023-10-17" @default.
- W1566754413 title "Pathomechanisms of nephrogenic systemic fibrosis: new insights" @default.
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- W1566754413 doi "https://doi.org/10.1111/j.1365-2230.2011.04136.x" @default.
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