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- W1566771121 abstract "A severe hypoxic/ischemic insult to the developing brain can lead to permanent neurological impairment and in some cases result in infant death. In Australia, approximately 3.5% of perinatal deaths can be attributed to asphyxia annually. Current clinical practice fails to detect the occurrence of hypoxia antepartum, the period in which hypoxic/ischemic neuropathology has been shown to primarily occur. Rapid identification and intervention of asphyxia during and following birth is crucial for reducing the risk of lifelong disability or death. The numerous biochemical cascades through which neuronal cell death occurs offers the potential for minimizing neuropathological damage due to the many different points in these pathways where cellular injury can be interrupted or in some cases reversed. A comparison of a constant and variable hypoxic/ischemic insult was performed to determine which insult is more effective in producing a consistent degree of survivable neuropathological damage in a newborn piglet model of perinatal asphyxia and, to identify which physiological responses may contribute to obtaining this ‘desirable outcome’. Fifty-one day old piglets were subjected to either a constant hypoxic/ischemic insult (FiO2 4%; n = 23) of 30-37 min duration or a variable hypoxic/ischemic insult (FiO2 2-10%; n = 16) of 30 min low amplitude cerebral function (LAEEG) including 10 min of low mean arterial blood pressure (MABP; <70% of baseline). Control animals were subjected to FiO2 21% (n = 12). At 72 h the piglets were euthanased, their brains removed and fixed in 4% paraformaldehyde and assessed for hypoxic/ischemic injury by histological analysis. Based on histology scores, piglets were grouped as undamaged or damaged; piglets that did not survive to 72 h were grouped separately as dead. The variable insult resulted in a greater number of piglets with neuropathological damage (undamaged = 12.5%, damaged = 68.75%, dead = 18.75%) while the constant insult resulted in a large proportion of undamaged piglets (undamaged = 50%, damaged = 22.2%, dead = 27.8%). Our results suggest that for a reliable degree of hypoxic/ischemic induced damage; a variable approach is the recommended paradigm." @default.
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- W1566771121 date "2004-01-01" @default.
- W1566771121 modified "2023-09-26" @default.
- W1566771121 title "Hypoxic/ischemic models in newborn piglet: a constant versus variable approach" @default.
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