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- W1566789323 abstract "Publisher Summary This chapter focuses on the biological aspects of depression. Depression is a state of low spirits or vitality. Psychiatrists divide depression into two types: endogenous, which is no apparent external cause, and reactive, which is an identifiable external cause, and while such a division may be of some value regarding ancillary treatment, there is currently no evidence to suggest that the biochemical changes that may be causally linked to the illness differ or any evidence that the ways in which the patient should be assisted by drugs differ substantially. Other international classifications of depression are based on the mono- and bipolar dichotomies that separate those patients with depressive symptoms only from those that fluctuate between depression and mania (i.e., manic depression) or have only manic symptoms. There are four major approaches to understanding the biochemical etiology of depression—namely, the analysis of postmortem brain of depressed suicide victims for neurotransmitters and their metabolites, the analysis of cerebrospinal fluid from depressed patients, the investigation of peripheral markers of neurotransmitter receptors by studying blood cells, for example, platelets and lymphocytes, and endocrine disturbances, which appear to be linked to the onset and duration of depression." @default.
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- W1566789323 date "2000-01-01" @default.
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- W1566789323 title "Chapter 9 Biological aspects of depression" @default.
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- W1566789323 doi "https://doi.org/10.1016/s1569-2582(00)80011-2" @default.
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