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- W1566807847 abstract "The efficacy and acceptability of PGF2alpha (prostaglandin F2alpha) as an abortifacient has been examined during intravenous infusion in 15 obstetrically normal midtrimester patients. Infusions of up to 200 mcg/minute of PGF2alpha induced complete abortions in 3 and incomplete abortions in an additional 3 patients. 4 patients failed to abort. All patients experienced undesirable side effects, i.e., nausea, vomiting, and diarrhea, in various degrees. This form of therapy cannot be recommended for routine therapeutic use; however, current clinical studies complemented by model experiments in animals suggest that the efficacy and acceptability of PGF2alpha can be increased by topical, intrauterine administration. Preliminary deductions pertinent to the mechanism of the abortifacient effect of PGF2alpha have been made based on measurements of intraamniotic pressure, circulating estradiol-17 beta, and progesterone levels." @default.
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- W1566807847 date "1971-12-01" @default.
- W1566807847 modified "2023-09-23" @default.
- W1566807847 title "The efficacy and acceptability of intravenously administered prostaglandin F2α as an abortifacient" @default.
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- W1566807847 doi "https://doi.org/10.1016/0002-9378(71)90104-9" @default.
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