FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566842563> ?p ?o ?g. }

• W1566842563 endingPage "554" @default.
• W1566842563 startingPage "546" @default.
• W1566842563 abstract "Summary Measurement of erythrocyte [red blood cells (RBC)] complement receptor type 1 (CR1, CD35) has the potential to serve as a sensitive assessment of complement activation and immune complex clearance. All previously reported monoclonal antibodies (MoAb) to the extracellular region of CR1 recognize epitopes within the long homologous repeats (LHR) of CR1 and the epitopes for the most frequently used MoAbs are repeated at least twice per CR1 molecule. Furthermore, CR1 exhibits structural polymorphism characterized by a variable number of LHR per molecule. Thus, accurate enumeration of cell surface CR1 using currently available MoAb would require that the results be corrected for the number of antibody epitopes per CR1 molecule encoded by each individual's alleles. To obtain a MoAb to a non-polymorphic epitope on human CR1, hybridomas were generated from mice immunized with recombinant soluble CR1 (sCR1) and MoAb were screened for those that recognized the full-length extracellular domain but failed to bind to all four recombinant LHR fragments. A single antibody, CR1-2B11, was identified and was found to recognize an epitope located wholly within SCR29-30 of CR1, NH2-terminal to an elastase cleavage site. Like other CR1 MoAb, the CR1-2B11 epitope expression decreased on old erythrocytes compared to younger cells and CR1-2B11 did not identify a CR1 ‘stump’ on RBC. Importantly, CR1-2B11 immunofluorescence did not change with storage or handling of RBC, unlike the apparent decrease in immunofluorescence observed with other MoAb. CR1-2B11 should be useful for the accurate enumeration of RBC CR1." @default.
• W1566842563 created "2016-06-24" @default.
• W1566842563 creator A5006987371 @default.
• W1566842563 creator A5012886188 @default.
• W1566842563 creator A5013693987 @default.
• W1566842563 creator A5024547892 @default.
• W1566842563 creator A5045714342 @default.
• W1566842563 creator A5078607812 @default.
• W1566842563 creator A5089007696 @default.
• W1566842563 date "2007-03-09" @default.
• W1566842563 modified "2023-10-18" @default.
• W1566842563 title "Antibody CR1-2B11 recognizes a non-polymorphic epitope of human CR1 (CD35)" @default.
• W1566842563 cites W123679325 @default.
• W1566842563 cites W1402398 @default.
• W1566842563 cites W1524566840 @default.
• W1566842563 cites W1531489831 @default.
• W1566842563 cites W1555407201 @default.
• W1566842563 cites W1568648064 @default.
• W1566842563 cites W1569662926 @default.
• W1566842563 cites W1968489524 @default.
• W1566842563 cites W1982638287 @default.
• W1566842563 cites W1983623796 @default.
• W1566842563 cites W1989916780 @default.
• W1566842563 cites W1998528076 @default.
• W1566842563 cites W2001074919 @default.
• W1566842563 cites W2021023909 @default.
• W1566842563 cites W2031383126 @default.
• W1566842563 cites W2055785572 @default.
• W1566842563 cites W2060983879 @default.
• W1566842563 cites W2073698274 @default.
• W1566842563 cites W2078993958 @default.
• W1566842563 cites W2079291696 @default.
• W1566842563 cites W2082610073 @default.
• W1566842563 cites W2096706092 @default.
• W1566842563 cites W2101988870 @default.
• W1566842563 cites W2111185645 @default.
• W1566842563 cites W2126902910 @default.
• W1566842563 cites W2140799426 @default.
• W1566842563 cites W2171118517 @default.
• W1566842563 cites W2310464721 @default.
• W1566842563 cites W2338465937 @default.
• W1566842563 doi "https://doi.org/10.1111/j.1365-2249.2007.03355.x" @default.
• W1566842563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1941935" @default.
• W1566842563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17493021" @default.
• W1566842563 hasPublicationYear "2007" @default.
• W1566842563 type Work @default.
• W1566842563 sameAs 1566842563 @default.
• W1566842563 citedByCount "10" @default.
• W1566842563 countsByYear W15668425632013 @default.
• W1566842563 countsByYear W15668425632014 @default.
• W1566842563 countsByYear W15668425632015 @default.
• W1566842563 countsByYear W15668425632016 @default.
• W1566842563 countsByYear W15668425632017 @default.
• W1566842563 crossrefType "journal-article" @default.
• W1566842563 hasAuthorship W1566842563A5006987371 @default.
• W1566842563 hasAuthorship W1566842563A5012886188 @default.
• W1566842563 hasAuthorship W1566842563A5013693987 @default.
• W1566842563 hasAuthorship W1566842563A5024547892 @default.
• W1566842563 hasAuthorship W1566842563A5045714342 @default.
• W1566842563 hasAuthorship W1566842563A5078607812 @default.
• W1566842563 hasAuthorship W1566842563A5089007696 @default.
• W1566842563 hasBestOaLocation W15668425631 @default.
• W1566842563 hasConcept C104317684 @default.
• W1566842563 hasConcept C111684460 @default.
• W1566842563 hasConcept C147483822 @default.
• W1566842563 hasConcept C153911025 @default.
• W1566842563 hasConcept C159654299 @default.
• W1566842563 hasConcept C195616568 @default.
• W1566842563 hasConcept C203014093 @default.
• W1566842563 hasConcept C2778236600 @default.
• W1566842563 hasConcept C2781241564 @default.
• W1566842563 hasConcept C2910041089 @default.
• W1566842563 hasConcept C40767141 @default.
• W1566842563 hasConcept C542903549 @default.
• W1566842563 hasConcept C55493867 @default.
• W1566842563 hasConcept C86803240 @default.
• W1566842563 hasConceptScore W1566842563C104317684 @default.
• W1566842563 hasConceptScore W1566842563C111684460 @default.
• W1566842563 hasConceptScore W1566842563C147483822 @default.
• W1566842563 hasConceptScore W1566842563C153911025 @default.
• W1566842563 hasConceptScore W1566842563C159654299 @default.
• W1566842563 hasConceptScore W1566842563C195616568 @default.
• W1566842563 hasConceptScore W1566842563C203014093 @default.
• W1566842563 hasConceptScore W1566842563C2778236600 @default.
• W1566842563 hasConceptScore W1566842563C2781241564 @default.
• W1566842563 hasConceptScore W1566842563C2910041089 @default.
• W1566842563 hasConceptScore W1566842563C40767141 @default.
• W1566842563 hasConceptScore W1566842563C542903549 @default.
• W1566842563 hasConceptScore W1566842563C55493867 @default.
• W1566842563 hasConceptScore W1566842563C86803240 @default.
• W1566842563 hasIssue "3" @default.
• W1566842563 hasLocation W15668425631 @default.
• W1566842563 hasLocation W15668425632 @default.
• W1566842563 hasLocation W15668425633 @default.
• W1566842563 hasOpenAccess W1566842563 @default.
• W1566842563 hasPrimaryLocation W15668425631 @default.
• W1566842563 hasRelatedWork W2001011716 @default.
• W1566842563 hasRelatedWork W2019166448 @default.

• next