Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566843617> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1566843617 endingPage "4204" @default.
- W1566843617 startingPage "4197" @default.
- W1566843617 abstract "Abstract Fas is an apoptosis-signaling receptor that triggers cell death upon binding to its ligand (FasL). Autoimmune-prone MRL/lpr mice, characterized by a spontaneous mutation of Fas, exhibit a defect in the activation-induced cell death of mature T cells through a Fas-mediated pathway. As a consequence of this defect, activated T cells accumulating in this strain overexpress the FasL and can therefore mediate in vitro Fas-dependent cytotoxicity. To determine whether hepatic injury could be the result of an interaction between T lymphocytes bearing FasL and Fas-expressing liver cells, the livers of lethally irradiated MRL+/+ recipients reconstituted with MRL/lpr lymphoid cells were studied. After transfer of MRL/lpr spleen cells, livers were infiltrated by polyclonal CD8+ T lymphocytes of lpr origin with a peak on day 21 postgrafting. These donor-derived intrahepatic lymphocytes overexpressed the FasL and exerted in vitro Fas-mediated cytotoxicity against Fas+ thymocytes, which was specifically inhibited by soluble recombinant Fas in a dose-dependent manner. These intrahepatic lymphocytes induced apoptosis in vitro, irrespective of MHC restriction, in Fas-expressing primary cultured hepatocytes. Histologic examination of the liver revealed severe endothelialitis as well as periportal and intralobular infiltrations of activated lymphocytes with apoptotic hepatocytes in their vicinity. Simultaneously, liver damage was ascertained by elevated serum transaminase levels. These observations support the notion that an Ag-independent mechanism involving FasL may play a role in certain liver pathologies." @default.
- W1566843617 created "2016-06-24" @default.
- W1566843617 creator A5003003804 @default.
- W1566843617 creator A5037648651 @default.
- W1566843617 creator A5042482783 @default.
- W1566843617 creator A5048757958 @default.
- W1566843617 creator A5060379556 @default.
- W1566843617 creator A5069746943 @default.
- W1566843617 creator A5090315253 @default.
- W1566843617 date "1997-11-01" @default.
- W1566843617 modified "2023-10-18" @default.
- W1566843617 title "Fas-mediated liver damage in MRL hemopoietic chimeras undergoing lpr-mediated graft-versus-host disease." @default.
- W1566843617 doi "https://doi.org/10.4049/jimmunol.159.9.4197" @default.
- W1566843617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9379013" @default.
- W1566843617 hasPublicationYear "1997" @default.
- W1566843617 type Work @default.
- W1566843617 sameAs 1566843617 @default.
- W1566843617 citedByCount "21" @default.
- W1566843617 countsByYear W15668436172013 @default.
- W1566843617 countsByYear W15668436172015 @default.
- W1566843617 countsByYear W15668436172022 @default.
- W1566843617 crossrefType "journal-article" @default.
- W1566843617 hasAuthorship W1566843617A5003003804 @default.
- W1566843617 hasAuthorship W1566843617A5037648651 @default.
- W1566843617 hasAuthorship W1566843617A5042482783 @default.
- W1566843617 hasAuthorship W1566843617A5048757958 @default.
- W1566843617 hasAuthorship W1566843617A5060379556 @default.
- W1566843617 hasAuthorship W1566843617A5069746943 @default.
- W1566843617 hasAuthorship W1566843617A5090315253 @default.
- W1566843617 hasBestOaLocation W15668436171 @default.
- W1566843617 hasConcept C109316439 @default.
- W1566843617 hasConcept C153911025 @default.
- W1566843617 hasConcept C167672396 @default.
- W1566843617 hasConcept C190283241 @default.
- W1566843617 hasConcept C202751555 @default.
- W1566843617 hasConcept C203014093 @default.
- W1566843617 hasConcept C3031857 @default.
- W1566843617 hasConcept C31573885 @default.
- W1566843617 hasConcept C502942594 @default.
- W1566843617 hasConcept C55493867 @default.
- W1566843617 hasConcept C66008609 @default.
- W1566843617 hasConcept C86803240 @default.
- W1566843617 hasConcept C8891405 @default.
- W1566843617 hasConceptScore W1566843617C109316439 @default.
- W1566843617 hasConceptScore W1566843617C153911025 @default.
- W1566843617 hasConceptScore W1566843617C167672396 @default.
- W1566843617 hasConceptScore W1566843617C190283241 @default.
- W1566843617 hasConceptScore W1566843617C202751555 @default.
- W1566843617 hasConceptScore W1566843617C203014093 @default.
- W1566843617 hasConceptScore W1566843617C3031857 @default.
- W1566843617 hasConceptScore W1566843617C31573885 @default.
- W1566843617 hasConceptScore W1566843617C502942594 @default.
- W1566843617 hasConceptScore W1566843617C55493867 @default.
- W1566843617 hasConceptScore W1566843617C66008609 @default.
- W1566843617 hasConceptScore W1566843617C86803240 @default.
- W1566843617 hasConceptScore W1566843617C8891405 @default.
- W1566843617 hasIssue "9" @default.
- W1566843617 hasLocation W15668436171 @default.
- W1566843617 hasLocation W15668436172 @default.
- W1566843617 hasOpenAccess W1566843617 @default.
- W1566843617 hasPrimaryLocation W15668436171 @default.
- W1566843617 hasRelatedWork W1991383991 @default.
- W1566843617 hasRelatedWork W2024503661 @default.
- W1566843617 hasRelatedWork W2044683642 @default.
- W1566843617 hasRelatedWork W2048728216 @default.
- W1566843617 hasRelatedWork W2066728513 @default.
- W1566843617 hasRelatedWork W2084186670 @default.
- W1566843617 hasRelatedWork W2105789996 @default.
- W1566843617 hasRelatedWork W2147466370 @default.
- W1566843617 hasRelatedWork W2392861473 @default.
- W1566843617 hasRelatedWork W2423980849 @default.
- W1566843617 hasVolume "159" @default.
- W1566843617 isParatext "false" @default.
- W1566843617 isRetracted "false" @default.
- W1566843617 magId "1566843617" @default.
- W1566843617 workType "article" @default.