Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566854946> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1566854946 endingPage "10501" @default.
- W1566854946 startingPage "10497" @default.
- W1566854946 abstract "The specific activity of protein kinase C in rat skeletal myoblasts decreased when they were exposed for very short periods to isoproterenol, forskolin, dibutyryl cyclic AMP (Bt2cAMP), or the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). In the presence of Bt2cAMP or forskolin only the cytosolic but not the membrane-bound kinase activity was found to decrease. Treatment with TPA, however, led to a decrease in the activity of the enzyme both in the cytosolic as well as the membrane fractions. The effects observed in vivo could be duplicated in crude extracts of myoblasts incubated with cAMP analogues or TPA. In the presence of ATP, protein kinase C activity decreased considerably in crude cytosolic fractions treated with the cAMP analogues, but a requirement for ATP was not evident for the decrease in activity brought about by TPA. For the cAMP analogues the decrease in protein kinase C was also prevented by incubation of the extracts with an inhibitor of cAMP-dependent protein kinase. The regulation of protein kinase C by Bt2cAMP (but not by TPA) was altered in Rous sarcoma virus-transformed myoblasts. It is considered likely that a component affected by cAMP (probably a substrate for cAMP-dependent protein kinase) participates in the regulation of protein kinase C activity, and it is altered in unknown ways in transformed myoblasts." @default.
- W1566854946 created "2016-06-24" @default.
- W1566854946 creator A5025400851 @default.
- W1566854946 creator A5033884838 @default.
- W1566854946 creator A5059246968 @default.
- W1566854946 creator A5072484226 @default.
- W1566854946 date "1987-08-01" @default.
- W1566854946 modified "2023-09-30" @default.
- W1566854946 title "Regulation of protein kinase C by cyclic adenosine 3':5'-monophosphate and a tumor promoter in skeletal myoblasts." @default.
- W1566854946 cites W1480686961 @default.
- W1566854946 cites W1481123143 @default.
- W1566854946 cites W1486015064 @default.
- W1566854946 cites W1489116922 @default.
- W1566854946 cites W1527015272 @default.
- W1566854946 cites W1533548516 @default.
- W1566854946 cites W1537210834 @default.
- W1566854946 cites W1589354481 @default.
- W1566854946 cites W1775749144 @default.
- W1566854946 cites W1964839077 @default.
- W1566854946 cites W1973454785 @default.
- W1566854946 cites W1974170868 @default.
- W1566854946 cites W1996626295 @default.
- W1566854946 cites W1997290852 @default.
- W1566854946 cites W2008245136 @default.
- W1566854946 cites W2010820226 @default.
- W1566854946 cites W2022867226 @default.
- W1566854946 cites W2027720409 @default.
- W1566854946 cites W2030706296 @default.
- W1566854946 cites W2068877244 @default.
- W1566854946 cites W2076690965 @default.
- W1566854946 cites W2095723732 @default.
- W1566854946 cites W2119073637 @default.
- W1566854946 cites W2178536469 @default.
- W1566854946 cites W2183970233 @default.
- W1566854946 cites W7299164 @default.
- W1566854946 cites W2009179943 @default.
- W1566854946 doi "https://doi.org/10.1016/s0021-9258(18)60988-3" @default.
- W1566854946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3038883" @default.
- W1566854946 hasPublicationYear "1987" @default.
- W1566854946 type Work @default.
- W1566854946 sameAs 1566854946 @default.
- W1566854946 citedByCount "38" @default.
- W1566854946 crossrefType "journal-article" @default.
- W1566854946 hasAuthorship W1566854946A5025400851 @default.
- W1566854946 hasAuthorship W1566854946A5033884838 @default.
- W1566854946 hasAuthorship W1566854946A5059246968 @default.
- W1566854946 hasAuthorship W1566854946A5072484226 @default.
- W1566854946 hasBestOaLocation W15668549461 @default.
- W1566854946 hasConcept C126322002 @default.
- W1566854946 hasConcept C134018914 @default.
- W1566854946 hasConcept C153911025 @default.
- W1566854946 hasConcept C184235292 @default.
- W1566854946 hasConcept C185592680 @default.
- W1566854946 hasConcept C207200792 @default.
- W1566854946 hasConcept C2776991684 @default.
- W1566854946 hasConcept C2779959927 @default.
- W1566854946 hasConcept C55493867 @default.
- W1566854946 hasConcept C71924100 @default.
- W1566854946 hasConcept C82495950 @default.
- W1566854946 hasConcept C86803240 @default.
- W1566854946 hasConcept C95444343 @default.
- W1566854946 hasConcept C97029542 @default.
- W1566854946 hasConceptScore W1566854946C126322002 @default.
- W1566854946 hasConceptScore W1566854946C134018914 @default.
- W1566854946 hasConceptScore W1566854946C153911025 @default.
- W1566854946 hasConceptScore W1566854946C184235292 @default.
- W1566854946 hasConceptScore W1566854946C185592680 @default.
- W1566854946 hasConceptScore W1566854946C207200792 @default.
- W1566854946 hasConceptScore W1566854946C2776991684 @default.
- W1566854946 hasConceptScore W1566854946C2779959927 @default.
- W1566854946 hasConceptScore W1566854946C55493867 @default.
- W1566854946 hasConceptScore W1566854946C71924100 @default.
- W1566854946 hasConceptScore W1566854946C82495950 @default.
- W1566854946 hasConceptScore W1566854946C86803240 @default.
- W1566854946 hasConceptScore W1566854946C95444343 @default.
- W1566854946 hasConceptScore W1566854946C97029542 @default.
- W1566854946 hasIssue "22" @default.
- W1566854946 hasLocation W15668549461 @default.
- W1566854946 hasOpenAccess W1566854946 @default.
- W1566854946 hasPrimaryLocation W15668549461 @default.
- W1566854946 hasRelatedWork W1965943749 @default.
- W1566854946 hasRelatedWork W1974568996 @default.
- W1566854946 hasRelatedWork W2016840789 @default.
- W1566854946 hasRelatedWork W2026105695 @default.
- W1566854946 hasRelatedWork W2048328229 @default.
- W1566854946 hasRelatedWork W2081376013 @default.
- W1566854946 hasRelatedWork W2144576666 @default.
- W1566854946 hasRelatedWork W2309978229 @default.
- W1566854946 hasRelatedWork W2463478234 @default.
- W1566854946 hasRelatedWork W4383602876 @default.
- W1566854946 hasVolume "262" @default.
- W1566854946 isParatext "false" @default.
- W1566854946 isRetracted "false" @default.
- W1566854946 magId "1566854946" @default.
- W1566854946 workType "article" @default.