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- W1566859644 abstract "This chapter discusses about the development of cartilage and bone. The skeletons of vertebrates are remarkably similar. Centuries of studies of bone morphology and the fact that bones are preserved as fossils has revealed that identical bones form much of the skull, vertebrae, and appendicular skeleton in fish, amphibians, reptiles, and mammals. Genetic studies in humans, mice, and zebrafish are now revealing that these similarities reflect similar developmental mechanisms underlying skeletal morphogenesis. Mutant screens in zebrafish have identified many genes required for early cartilage development and a number of these mutations are also associated with craniofacial syndromes in humans. This chapter summarizes the current methods for visualizing cartilage and bones that make zebrafish an excellent genetic model for dissecting the molecular basis of skeletal development. Further, we describe methods of screening for mutants with anomalous craniofacial and other skeletal phenotypes." @default.
- W1566859644 created "2016-06-24" @default.
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- W1566859644 date "2004-01-01" @default.
- W1566859644 modified "2023-10-09" @default.
- W1566859644 title "Development of Cartilage and Bone" @default.
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- W1566859644 doi "https://doi.org/10.1016/s0091-679x(04)76018-5" @default.
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