Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566864022> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1566864022 endingPage "4" @default.
- W1566864022 startingPage "1400" @default.
- W1566864022 abstract "Ataxia telangiectasia (AT) is a recessive genetic disease featuring neurodegeneration, immunodeficiency, chromosomal instability, radiation hypersensitivity, and increased predisposition to cancer. Reduced or delayed induction of the tumor suppressor protein p53 after gamma -irradiation was reported. These characteristics may be compatible with an inability to correctly regulate apoptosis. We show here that AT lymphocytes and EBV-transformed lymphoblasts demonstrate a significantly higher level of spontaneous apoptosis, whereas ionizing radiation-induced apoptosis is reduced compared to normal cells. However, neither AT nor normal primary fibroblasts undergo apoptosis after irradiation. Consequently, we conclude that the radiosensitivity of the AT cells is not related to an increased apoptotic response. Finally, we show that SV40-transformed AT fibroblasts undergo gamma- ray-induced apoptosis, while SV40-transformed normal cells do not. This result raises the question of the physiological relevance of the latter cellular model with respect to the AT phenotype." @default.
- W1566864022 created "2016-06-24" @default.
- W1566864022 creator A5007664834 @default.
- W1566864022 creator A5028680338 @default.
- W1566864022 creator A5041927531 @default.
- W1566864022 creator A5073267808 @default.
- W1566864022 creator A5075923652 @default.
- W1566864022 creator A5077661191 @default.
- W1566864022 date "1996-03-15" @default.
- W1566864022 modified "2023-10-18" @default.
- W1566864022 title "Deregulated apoptosis in ataxia telangiectasia: association with clinical stigmata and radiosensitivity." @default.
- W1566864022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8640831" @default.
- W1566864022 hasPublicationYear "1996" @default.
- W1566864022 type Work @default.
- W1566864022 sameAs 1566864022 @default.
- W1566864022 citedByCount "29" @default.
- W1566864022 countsByYear W15668640222015 @default.
- W1566864022 countsByYear W15668640222016 @default.
- W1566864022 countsByYear W15668640222018 @default.
- W1566864022 crossrefType "journal-article" @default.
- W1566864022 hasAuthorship W1566864022A5007664834 @default.
- W1566864022 hasAuthorship W1566864022A5028680338 @default.
- W1566864022 hasAuthorship W1566864022A5041927531 @default.
- W1566864022 hasAuthorship W1566864022A5073267808 @default.
- W1566864022 hasAuthorship W1566864022A5075923652 @default.
- W1566864022 hasAuthorship W1566864022A5077661191 @default.
- W1566864022 hasConcept C104317684 @default.
- W1566864022 hasConcept C111337013 @default.
- W1566864022 hasConcept C113842279 @default.
- W1566864022 hasConcept C121332964 @default.
- W1566864022 hasConcept C126322002 @default.
- W1566864022 hasConcept C127716648 @default.
- W1566864022 hasConcept C142724271 @default.
- W1566864022 hasConcept C143425029 @default.
- W1566864022 hasConcept C18231593 @default.
- W1566864022 hasConcept C185544564 @default.
- W1566864022 hasConcept C190283241 @default.
- W1566864022 hasConcept C203014093 @default.
- W1566864022 hasConcept C206684579 @default.
- W1566864022 hasConcept C2776925932 @default.
- W1566864022 hasConcept C2777607303 @default.
- W1566864022 hasConcept C2779134260 @default.
- W1566864022 hasConcept C2779486608 @default.
- W1566864022 hasConcept C502942594 @default.
- W1566864022 hasConcept C509974204 @default.
- W1566864022 hasConcept C54355233 @default.
- W1566864022 hasConcept C552990157 @default.
- W1566864022 hasConcept C71924100 @default.
- W1566864022 hasConcept C81885089 @default.
- W1566864022 hasConcept C86803240 @default.
- W1566864022 hasConcept C8891405 @default.
- W1566864022 hasConceptScore W1566864022C104317684 @default.
- W1566864022 hasConceptScore W1566864022C111337013 @default.
- W1566864022 hasConceptScore W1566864022C113842279 @default.
- W1566864022 hasConceptScore W1566864022C121332964 @default.
- W1566864022 hasConceptScore W1566864022C126322002 @default.
- W1566864022 hasConceptScore W1566864022C127716648 @default.
- W1566864022 hasConceptScore W1566864022C142724271 @default.
- W1566864022 hasConceptScore W1566864022C143425029 @default.
- W1566864022 hasConceptScore W1566864022C18231593 @default.
- W1566864022 hasConceptScore W1566864022C185544564 @default.
- W1566864022 hasConceptScore W1566864022C190283241 @default.
- W1566864022 hasConceptScore W1566864022C203014093 @default.
- W1566864022 hasConceptScore W1566864022C206684579 @default.
- W1566864022 hasConceptScore W1566864022C2776925932 @default.
- W1566864022 hasConceptScore W1566864022C2777607303 @default.
- W1566864022 hasConceptScore W1566864022C2779134260 @default.
- W1566864022 hasConceptScore W1566864022C2779486608 @default.
- W1566864022 hasConceptScore W1566864022C502942594 @default.
- W1566864022 hasConceptScore W1566864022C509974204 @default.
- W1566864022 hasConceptScore W1566864022C54355233 @default.
- W1566864022 hasConceptScore W1566864022C552990157 @default.
- W1566864022 hasConceptScore W1566864022C71924100 @default.
- W1566864022 hasConceptScore W1566864022C81885089 @default.
- W1566864022 hasConceptScore W1566864022C86803240 @default.
- W1566864022 hasConceptScore W1566864022C8891405 @default.
- W1566864022 hasIssue "6" @default.
- W1566864022 hasLocation W15668640221 @default.
- W1566864022 hasOpenAccess W1566864022 @default.
- W1566864022 hasPrimaryLocation W15668640221 @default.
- W1566864022 hasRelatedWork W106396820 @default.
- W1566864022 hasRelatedWork W1566864022 @default.
- W1566864022 hasRelatedWork W2017212532 @default.
- W1566864022 hasRelatedWork W2046395845 @default.
- W1566864022 hasRelatedWork W2085485064 @default.
- W1566864022 hasRelatedWork W2110401200 @default.
- W1566864022 hasRelatedWork W2127138236 @default.
- W1566864022 hasRelatedWork W2129868577 @default.
- W1566864022 hasRelatedWork W2550319874 @default.
- W1566864022 hasRelatedWork W2894680115 @default.
- W1566864022 hasVolume "56" @default.
- W1566864022 isParatext "false" @default.
- W1566864022 isRetracted "false" @default.
- W1566864022 magId "1566864022" @default.
- W1566864022 workType "article" @default.