Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566874548> ?p ?o ?g. }
- W1566874548 abstract "ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases (NDDs) and promising results have been obtained in the recent years. However, the underlying molecular and cellular mechanisms are not fully understood and different models have been proposed for neurodegenerative disorders. Here, we aim to review the current knowledge obtained for NDDs identifying common mechanisms as well as disease-specific models. In addition to the role of ROCK in different cell types such as neurons and microglia, we focus on the molecular signaling-pathways which mediate the beneficial effects of ROCK. Besides canonical ROCK signaling, modulation of neighboring pathways by non-canonical ROCK-crosstalk is a recurrent pattern in many NDD-model systems and has been suggested to mediate beneficial effects of ROCK-inhibition." @default.
- W1566874548 created "2016-06-24" @default.
- W1566874548 creator A5049273464 @default.
- W1566874548 creator A5069733042 @default.
- W1566874548 creator A5079995248 @default.
- W1566874548 date "2015-06-02" @default.
- W1566874548 modified "2023-10-01" @default.
- W1566874548 title "Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders" @default.
- W1566874548 cites W1498274359 @default.
- W1566874548 cites W1520845220 @default.
- W1566874548 cites W1527671059 @default.
- W1566874548 cites W1540745960 @default.
- W1566874548 cites W1541377218 @default.
- W1566874548 cites W1593989848 @default.
- W1566874548 cites W196680064 @default.
- W1566874548 cites W1967847339 @default.
- W1566874548 cites W1968751180 @default.
- W1566874548 cites W1972752407 @default.
- W1566874548 cites W1974448552 @default.
- W1566874548 cites W1978700598 @default.
- W1566874548 cites W1978757317 @default.
- W1566874548 cites W1980477780 @default.
- W1566874548 cites W1982853502 @default.
- W1566874548 cites W1983733701 @default.
- W1566874548 cites W1984962080 @default.
- W1566874548 cites W1985843533 @default.
- W1566874548 cites W1985929042 @default.
- W1566874548 cites W1986913568 @default.
- W1566874548 cites W1990422584 @default.
- W1566874548 cites W1995564969 @default.
- W1566874548 cites W1996017879 @default.
- W1566874548 cites W1998319940 @default.
- W1566874548 cites W2000054525 @default.
- W1566874548 cites W2001448765 @default.
- W1566874548 cites W2004236963 @default.
- W1566874548 cites W2004727491 @default.
- W1566874548 cites W2006534012 @default.
- W1566874548 cites W2006982581 @default.
- W1566874548 cites W2016773172 @default.
- W1566874548 cites W2017739035 @default.
- W1566874548 cites W2018644247 @default.
- W1566874548 cites W2018928754 @default.
- W1566874548 cites W2019546599 @default.
- W1566874548 cites W2025339136 @default.
- W1566874548 cites W2029848555 @default.
- W1566874548 cites W2030472096 @default.
- W1566874548 cites W2031164346 @default.
- W1566874548 cites W2035595951 @default.
- W1566874548 cites W2040547343 @default.
- W1566874548 cites W2043926237 @default.
- W1566874548 cites W2044763315 @default.
- W1566874548 cites W2050137574 @default.
- W1566874548 cites W2051758640 @default.
- W1566874548 cites W2054368903 @default.
- W1566874548 cites W2054380003 @default.
- W1566874548 cites W2056982361 @default.
- W1566874548 cites W2058182560 @default.
- W1566874548 cites W2059442573 @default.
- W1566874548 cites W2062059213 @default.
- W1566874548 cites W2063593499 @default.
- W1566874548 cites W2069637482 @default.
- W1566874548 cites W2069893872 @default.
- W1566874548 cites W2070348492 @default.
- W1566874548 cites W2070448139 @default.
- W1566874548 cites W2070669288 @default.
- W1566874548 cites W2071249297 @default.
- W1566874548 cites W2071663291 @default.
- W1566874548 cites W2072185199 @default.
- W1566874548 cites W2074548912 @default.
- W1566874548 cites W2076429912 @default.
- W1566874548 cites W2076585467 @default.
- W1566874548 cites W2077003881 @default.
- W1566874548 cites W2077739050 @default.
- W1566874548 cites W2077834462 @default.
- W1566874548 cites W2085375372 @default.
- W1566874548 cites W2088151363 @default.
- W1566874548 cites W2088987148 @default.
- W1566874548 cites W2091261568 @default.
- W1566874548 cites W2094589299 @default.
- W1566874548 cites W2096386031 @default.
- W1566874548 cites W2099160207 @default.
- W1566874548 cites W2106056374 @default.
- W1566874548 cites W2107288853 @default.
- W1566874548 cites W2108718949 @default.
- W1566874548 cites W2109559424 @default.
- W1566874548 cites W2111200377 @default.
- W1566874548 cites W2111442935 @default.
- W1566874548 cites W2112516420 @default.
- W1566874548 cites W2121642311 @default.
- W1566874548 cites W2123431154 @default.
- W1566874548 cites W2128918441 @default.
- W1566874548 cites W2132621835 @default.
- W1566874548 cites W2135636923 @default.
- W1566874548 cites W2141771317 @default.
- W1566874548 cites W2150656456 @default.
- W1566874548 cites W2151199043 @default.
- W1566874548 cites W2154357643 @default.
- W1566874548 cites W2160615365 @default.
- W1566874548 cites W2166884070 @default.
- W1566874548 cites W2167693778 @default.