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- W1566902236 abstract "Objective To investigate the relationship among microsatellite alterations on chromosome 9(9p) and the oncogenesis,metastasis of non-small cell lung cancer (NSCLC).Methods Two microsatellite markers,IFNA and D9S171,were analyzed in 32 cases of NSCLC by polymerase chain reaction-based silver-staining assay.Results Of 32 cases of NSCLC,14(43.8％) had microsatellite alterations.The alteration frequency was 64.7％ in NSCLC with lymph node metastasis,and 20％ in those without lymph node metastasis.There was significant difference between the two groups.None of benign lung tissues showed microsatellite alterations.Conclusion Microsatellite alteration on chromosome 9p in NSCLC appears to be a common and specific event,and may be a valuable molecular marker for determination of early diagnosis and metastasis of NSCLC.DOI: 10.3779/j.issn.1009-3419.2000.05.15" @default.
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- W1566902236 date "2000-10-20" @default.
- W1566902236 modified "2023-09-27" @default.
- W1566902236 title "[Correlation of microsatellite alterations on chromosome 9 and oncogenesis,metastasis in NSCLC]." @default.
- W1566902236 doi "https://doi.org/10.3779/j.issn.1009-3419.2000.05.15" @default.
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