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- W1566932041 abstract "Summary 1.Fifty unselected patients with jaundice and hepatomegaly were studied with multiple liver function tests and needle biopsies. 2.The data obtained by history confirm the relatively higher incidence of portal cirrhosis in males and the high rate of alcoholism in patients with this condition. 3.Ascites, when not associated with portal cirrhosis, was due to malignancy. 4.The size of the liver and the presence or absence of splenomegaly, fever, and anemia were of no significance in the differential diagnosis of portal cirrhosis and post-hepatic obstruction. 5.The cephalin flocculation and alkaline phosphatase tests were the tests of liver function which were most consistently helpful in the differential diagnosis. 6.In 72 per cent of the patients the laboratory data and histologic findings were consistent with the clinical diagnosis. 7.In an additional 12 per cent the clinical diagnosis was substantiated by the needle biopsy, although it was not in agreement with the initial interpretation of the liver function tests. 8.In 4 per cent of the series the liver function tests altered the original clinical impression and were upheld by biopsy. 9.In 8 'per cent of the patients the histologic examination of tissue obtained by needle biopsy added to or altered the diagnosis made on the basis of clinical findings and laboratory data. 10.The biopsy findings were misleading or inadequate in 4 per cent of the cases. This failure occurred only in patients having more than one disease process involving the liver. 11.By careful correlation of the history, physical examination, laboratory liver function tests and needle biopsy of the liver, a positive diagnosis was made without surgical exploration in 94 per cent of 50 patients with jaundice and hepatomegaly." @default.
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- W1566932041 date "1953-05-01" @default.
- W1566932041 modified "2023-09-27" @default.
- W1566932041 title "The Differential Diagnosis of Jaundice: The Relative Value of the Clinical Impression, Laboratory Tests, and Aspiration Liver Biopsy" @default.
- W1566932041 cites W2106462956 @default.
- W1566932041 doi "https://doi.org/10.1016/s0016-5085(53)80063-6" @default.
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