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- W1566987430 abstract "CHEMICAL SYNTHESIS OF PEPTIDES AND PEPTIDE THIOESTERS by INDRAJEET SHARMA May 2011 Advisor: Dr. David Crich Major: Chemistry Degree: Doctor of Philosophy This dissertation describes investigations toward the development of a new chemistry for the block synthesis of peptides and peptidyl thioesters. A direct approach for the Fmoc-SPPS of peptidyl thioesters is also delineated in this thesis. In the first part of chapter one, the difficulty and importance of chemical synthesis of peptides is explained, and a brief survey of available methods is given. The second part of chapter one presents the challenges inherent in the synthesis of peptidyl thioesters by Fmoc-SPPS. The second chapter outlines the investigations conducted towards the development of a new chemistry for epimerization-free block synthesis of peptides from thioacids and amines by a process involving the in situ formation of highly active thioesters by nucleophilic aromatic substitution of C-terminal thioacids on electron-deficient halogenoarenes. The superiority of this new chemistry over available methods is illustrated through direct comparisons in the block synthesis of an octapeptide." @default.
- W1566987430 created "2016-06-24" @default.
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- W1566987430 date "2011-01-01" @default.
- W1566987430 modified "2023-09-26" @default.
- W1566987430 title "Chemical Synthesis Of Peptides And Peptide Thioesters" @default.
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