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- W1566987708 abstract "The signal in magnetic resonance imaging MRI sequences depends on chemical composition of tissues; cellular organization and metabolism are of little relevance. Diffusion-weighted images (DWI) is designed to evaluate diffusion movements of the molecules on a spatial axis. These incoherent microscopic molecular movements cause loss of phase of the protons and reduce signal intensity. Diffusion may be evaluated on a different spatial axis at different time/space scales, depending on the direction, timing, and strength of the applied magnetic field gradients. Signal may simply be converted into an image or may be further elaborated to obtain a quantitative map of the ADC. A region of restricted diffusion on a given spatial axis will appear hyperintense on the DWI and hypointense on the ADC maps. Diffusion in the tissues depends on capillary flow and on the intracellular movements requiring active metabolism. In addition proton magnetic resonance spectroscopy (PMRS) provides useful information, complementing that gained through MRI, with regard to cell membrane proliferation, neuronal damage, energy metabolism, and necrotic transformation of brain or tumor tissues. One needs to be able to interpret both images and the spectroscopy data accurately to derive information about the location, edema, mass effect, calcification, cyst formation, visualization, and contrast enhancement, given the patient's age and clinical presentation." @default.
- W1566987708 created "2016-06-24" @default.
- W1566987708 creator A5058866039 @default.
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- W1566987708 date "2010-01-01" @default.
- W1566987708 modified "2023-10-09" @default.
- W1566987708 title "Magnetic Resonance Imaging Diagnostics of Human Brain Disorders" @default.
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- W1566987708 doi "https://doi.org/10.1016/b978-0-12-384711-9.00003-8" @default.
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