FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567008488> ?p ?o ?g. }

• W1567008488 abstract "Genomic variability provides the basis for adaptation and evolution and constitutes a fascinating aspect of the metabolically and phylogenetically diverse microbial world. Variability in bacteria has been extensively studied both because it enables inferring evolutionary relationships and because it plays an important role in host-pathogen interactions. Microbiologists, who have long struggled with species classification, have gained a more recent appreciation of the level of genetic diversity in microorganisms that has led to new awareness of what may constitute a bacterial “species” (Doolittle & Zhaxybayeva, 2009). In the clinical setting, genomic variability can represent a significant barrier to treatment. Many pathogens can acquire mutations or foreign genetic material through horizontal gene transfer (HGT) in response to the selective pressure imposed by the host immune system and by chemotherapy (Hawkey & Jones, 2009, Sampson, 2011), resulting in strains that are difficult to eradicate in hospitals as well as during long-term infection. Understanding the extent of genomic variability and its effects on disease in the case of pathogens that display genetic homogeneity and low variability, as is the case for the causative agent of tuberculosis, Mycobacterium tuberculosis, is particularly fascinating. The success of M. tuberculosis is intimately tied to the infectious process and its interaction with the human host, which is believed to have resulted from a long process of co-evolution (Donoghue, 2009, Gutierrez et al., 2005). As a result, M. tuberculosis is capable of subverting the immune response and persisting as a latent form within an individual and for millennia within the human population." @default.
• W1567008488 created "2016-06-24" @default.
• W1567008488 creator A5025595162 @default.
• W1567008488 creator A5030566056 @default.
• W1567008488 creator A5037733049 @default.
• W1567008488 creator A5040260987 @default.
• W1567008488 creator A5049880246 @default.
• W1567008488 creator A5059744549 @default.
• W1567008488 creator A5061891239 @default.
• W1567008488 date "2012-02-17" @default.
• W1567008488 modified "2023-10-17" @default.
• W1567008488 title "Genomic Variability of Mycobacterium tuberculosis" @default.
• W1567008488 cites W1595527122 @default.
• W1567008488 cites W1606785910 @default.
• W1567008488 cites W1706293004 @default.
• W1567008488 cites W1804116733 @default.
• W1567008488 cites W1839760785 @default.
• W1567008488 cites W1884882993 @default.
• W1567008488 cites W1916435210 @default.
• W1567008488 cites W1920141485 @default.
• W1567008488 cites W1922405592 @default.
• W1567008488 cites W1969487341 @default.
• W1567008488 cites W1985986410 @default.
• W1567008488 cites W1986106712 @default.
• W1567008488 cites W1987355762 @default.
• W1567008488 cites W1994007828 @default.
• W1567008488 cites W1994534400 @default.
• W1567008488 cites W1997027430 @default.
• W1567008488 cites W1998203805 @default.
• W1567008488 cites W1999809115 @default.
• W1567008488 cites W2003025878 @default.
• W1567008488 cites W2005203688 @default.
• W1567008488 cites W2006128966 @default.
• W1567008488 cites W2007707812 @default.
• W1567008488 cites W2011185704 @default.
• W1567008488 cites W2011261850 @default.
• W1567008488 cites W2012515231 @default.
• W1567008488 cites W2013923392 @default.
• W1567008488 cites W2014897627 @default.
• W1567008488 cites W2015516142 @default.
• W1567008488 cites W2033415336 @default.
• W1567008488 cites W2036722597 @default.
• W1567008488 cites W2040031850 @default.
• W1567008488 cites W2042352041 @default.
• W1567008488 cites W2043532115 @default.
• W1567008488 cites W2044648876 @default.
• W1567008488 cites W2048017191 @default.
• W1567008488 cites W2052642114 @default.
• W1567008488 cites W2054822772 @default.
• W1567008488 cites W2054832549 @default.
• W1567008488 cites W2057212110 @default.
• W1567008488 cites W2066086624 @default.
• W1567008488 cites W2066321034 @default.
• W1567008488 cites W2072680575 @default.
• W1567008488 cites W2079497788 @default.
• W1567008488 cites W2083987421 @default.
• W1567008488 cites W2086796237 @default.
• W1567008488 cites W2087793347 @default.
• W1567008488 cites W2088101132 @default.
• W1567008488 cites W2088904392 @default.
• W1567008488 cites W2091385221 @default.
• W1567008488 cites W2099789145 @default.
• W1567008488 cites W2100267245 @default.
• W1567008488 cites W2100545837 @default.
• W1567008488 cites W2100887397 @default.
• W1567008488 cites W2101094926 @default.
• W1567008488 cites W2101995515 @default.
• W1567008488 cites W2102269841 @default.
• W1567008488 cites W2105513728 @default.
• W1567008488 cites W2106813347 @default.
• W1567008488 cites W2110949356 @default.
• W1567008488 cites W2112091811 @default.
• W1567008488 cites W2113265821 @default.
• W1567008488 cites W2115228083 @default.
• W1567008488 cites W2116234319 @default.
• W1567008488 cites W2117580564 @default.
• W1567008488 cites W2119603196 @default.
• W1567008488 cites W2120254719 @default.
• W1567008488 cites W2120619607 @default.
• W1567008488 cites W2123968179 @default.
• W1567008488 cites W2125913277 @default.
• W1567008488 cites W2126568957 @default.
• W1567008488 cites W2129015046 @default.
• W1567008488 cites W2129536819 @default.
• W1567008488 cites W2130462614 @default.
• W1567008488 cites W2131071075 @default.
• W1567008488 cites W2133385429 @default.
• W1567008488 cites W2134558351 @default.
• W1567008488 cites W2139803213 @default.
• W1567008488 cites W2142392294 @default.
• W1567008488 cites W2145188474 @default.
• W1567008488 cites W2147096313 @default.
• W1567008488 cites W2149893524 @default.
• W1567008488 cites W2150722133 @default.
• W1567008488 cites W2152363872 @default.
• W1567008488 cites W2153123187 @default.
• W1567008488 cites W2153522719 @default.
• W1567008488 cites W2156451686 @default.
• W1567008488 cites W2156484140 @default.
• W1567008488 cites W2157179706 @default.

• next