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• W1567010947 abstract "Abstract The alpha-thalassemic mouse has a hereditary microcytic anemia, almost certainly has a shortened RBC life span, and is a potential candidate for cell replacement therapy. In a routine study of bone marrow repopulating capacity using hemoglobin as a cell marker, normal donor marrow cells, but not alpha-thalassemic donor marrow cells, completely replaced the host cells. Further analysis showed that at least 30 times more alpha-thalassemic cells were required to outcompete normal donor cells injected simultaneously. The results were more extreme then expected and suggested a defect in a stem cell population as well as in the RBCs. Evidence that the multipotent and erythroid-committed stem cells in alpha-thalassemic mice are not decreased was shown by CFU-S and CFU-E assays. The combined results indicate that the deletion expresses itself most conspicuously in the RBC population. Tests were also performed to analyze repopulation kinetics in the Hbath-J/+ mice. In unirradiated alpha-thalassemic hosts, the hemoglobin from a normal donor persisted but did not replace the host hemoglobin. Sublethally irradiated alpha-thalassemic hosts, on the other hand, were easily repopulated with normal cells. We conclude that the alpha-thalassemic mouse is a good model for cell replacement therapy." @default.
• W1567010947 created "2016-06-24" @default.
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• W1567010947 creator A5046701088 @default.
• W1567010947 date "1985-09-01" @default.
• W1567010947 modified "2023-09-27" @default.
• W1567010947 title "The hematopoietic stem cells of alpha-thalassemic mice" @default.
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• W1567010947 doi "https://doi.org/10.1182/blood.v66.3.595.595" @default.
• W1567010947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3896346" @default.
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