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- W1567015123 abstract "C32 Human glioblastomas (GBM) overexpressed the interleukin-13 receptor (IL-13Rα2) that is absent or at every low level in the normal brain. The IL-13Rα2 is believed to act as a decoy receptor in that the binding of IL-13 to this receptor does not trigger any signal transduction. In a recent study, IL-13Rα2 was identified as one of the downstream targets of the truncated epidermal growth factor receptor (EGFRvIII) signaling using SAGE analysis (Lai et al., 2002). However, the functional significance of IL-13Rα2 in the presence of EGFRvIII remained unclear. Thus, the focus of this study is to dissect the functional role of IL-13Rα2 in the development of human gliomas. The levels of IL-13Rα2 transcripts in local brain tumor samples consisting of low- and high-grade were first examined and found to be overexpressed in mainly high-grade gliomas, suggesting the potential involvement of IL-13Rα2 in glioma progression. To examine the effect of overexpressed IL-13Rα2 in the presence of EGFRvIII , an expression cassette for IL-13Rα2 was stably introduced into an EGFRvIII overexpressed, human GBM cell line (ΔGli36) and the newly derived stable cell line was denoted as ΔG13RS. High level expression of both IL-13Rα2 and EGFRvIII proteins ΔG13RS cells was subsequently confirmed by western blot analysis. Cell cycle analysis showed that ΔG13RS exhibited an accelerated growth rate in the presence of IL-13Rα2 proteins, which were attributed to an increase in the percentage of proliferating S-phase cells and a corresponding decrease in the G 0 /G 1 and G 2 /M phase of the cell cycle. Colony formation assay further demonstrated that these cells exhibited anchorage independence growth and yielded significantly more colonies than the parental cells without IL-13Rα2. In addition, ΔG13RS also demonstrated augmented resistance to UV irradiation-induced apoptosis in vitro . Taken together, our results indicated that the tumorigenic potential of EGFRvIII-expressing human gliomas is further enhanced in the presence of IL-13Rα2. Thus, we hypothesize that these decoy IL-13Rα2 receptors do play a functional role in glioma progression. Current efforts are focused in elucidating the underlying mechanism of how IL-13Rα2 overexpression may confer a growth advantage in vitro and in vivo ." @default.
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- W1567015123 date "2007-11-15" @default.
- W1567015123 modified "2023-09-26" @default.
- W1567015123 title "More than a decoy receptor: Human interleukin-13 receptor alpha 2 (IL-13Rα2) promotes glioblastoma multiforme (GBM) cell growth in the presence of EGFRvIII" @default.
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