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- W1567103608 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20064555 Most commonly quoted proportions of cancers attributable to various causes derive from the estimates produced in the early 1980s by Doll and Peto. Since then, new information has accumulated on the identification of human carcinogens, the quantification of their effects and the prevalence of their exposure. We have performed a systematic review of the causes of human cancer and derived attributable risks based on results on meta- or pooled analyses and representative data on prevalence of exposure. We have used this evidence-based approach to calculate sex-specific attributable risks of cancer incidence and mortality in France in 2000. Our results on cancer incidence are presented in the table; they are similar to the results on cancer mortality. Tobacco is the main cause of cancer in France; alcohol drinking and reproductive factors are responsible for an important proportion of total cancers. The only nutritional factors responsible for a sizable number of cancers are overweight and obesity. The role of occupational exposures and pollutants appears to be smaller than previously reported. Known causes of cancer are responsible for approximately 45% of cancers in men and 35% in women. These figure are conservative and are not directly applicable to other countries. They stress stress the need for further fundamental and epidemiological research. The role of viruses and infections is probably underestimated as well as that of nutritional factors, especially during young age. They should be investigated and interactions better assessed.View this table:" @default.
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- W1567103608 date "2006-04-15" @default.
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- W1567103608 title "Attributable causes of cancers: an evidence-based approach" @default.
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