Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567106333> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1567106333 endingPage "9" @default.
- W1567106333 startingPage "23" @default.
- W1567106333 abstract "Protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure to radiation. Several physico-chemical and biological factors collectively contribute to the damage caused by radiation and are, therefore, targets for developing radioprotectors. Chemicals capable of scavenging free radicals, relieving oxidative stress, promoting antioxidant activity and modulating immune response have been some of the radioprotectors extensively investigated with limited success. It has long been known that some of the most effective radioprotective agents are those which contain sulphydryl groups. 4-amino-5-mercapto-3-methyl-1, 2, 4-triazole (AMMT) is one of the well-known 1, 2, 4 triazole derivatives with functional sulphydryl group. The present study reports an evaluation of radical scavenging and radioprotective properties of sulphydryl group containing triazole derivative. The lethal dose of electron beam radiation (EBR) was studied by survival assay. The dose reduction factor (DRF) of AMMT was calculated using the ratio between LD50 of EBR with and without AMMT treatment. Radical scavenging property of AMMT was assessed by DPPH radical scavenging assay. The clastogenic effects of EBR were recorded by Micronucleus test in bone marrow cells and DNA fragmentation assay in mice hepatic cells. The survival assay results showed that the LD50 of EBR was 10 Gy. The calculated DRF for AMMT was found to be 1.2. DPPH radical scavenging assay showed a positive result when it was compared with the standard glutathione. Treatment of mice with 100 mg of AMMT for 15 days before irradiation significantly (P<0.05) reduced the frequency of micronucleus formation in bone marrow cells and also reduced the DNA fragmentation in hepatic cells. The results obtained in the present study indicated that AMMT has a protective effect against the EBR-induced mortality and clastogenicity." @default.
- W1567106333 created "2016-06-24" @default.
- W1567106333 creator A5055955391 @default.
- W1567106333 creator A5058174389 @default.
- W1567106333 date "2015-01-20" @default.
- W1567106333 modified "2023-09-26" @default.
- W1567106333 title "Radioprotective effect of sulphydryl group containing triazole derivative to modulate the radiation- induced clastogenic effects." @default.
- W1567106333 cites W1489408430 @default.
- W1567106333 cites W1973101427 @default.
- W1567106333 cites W1978975074 @default.
- W1567106333 cites W1983480175 @default.
- W1567106333 cites W1987628776 @default.
- W1567106333 cites W1988397926 @default.
- W1567106333 cites W1988407527 @default.
- W1567106333 cites W1994246722 @default.
- W1567106333 cites W2021992780 @default.
- W1567106333 cites W2024255049 @default.
- W1567106333 cites W2035002706 @default.
- W1567106333 cites W2049322234 @default.
- W1567106333 cites W2049546900 @default.
- W1567106333 cites W2049589006 @default.
- W1567106333 cites W2063732325 @default.
- W1567106333 cites W2078047263 @default.
- W1567106333 cites W2085210827 @default.
- W1567106333 cites W2110454754 @default.
- W1567106333 cites W2158254997 @default.
- W1567106333 cites W2176085419 @default.
- W1567106333 cites W2340540305 @default.
- W1567106333 cites W2510043997 @default.
- W1567106333 cites W2510107045 @default.
- W1567106333 cites W2949707857 @default.
- W1567106333 cites W4245737639 @default.
- W1567106333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4292178" @default.
- W1567106333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25598796" @default.
- W1567106333 hasPublicationYear "2015" @default.
- W1567106333 type Work @default.
- W1567106333 sameAs 1567106333 @default.
- W1567106333 citedByCount "1" @default.
- W1567106333 countsByYear W15671063332015 @default.
- W1567106333 crossrefType "journal-article" @default.
- W1567106333 hasAuthorship W1567106333A5055955391 @default.
- W1567106333 hasAuthorship W1567106333A5058174389 @default.
- W1567106333 hasConcept C139066938 @default.
- W1567106333 hasConcept C178790620 @default.
- W1567106333 hasConcept C181199279 @default.
- W1567106333 hasConcept C185592680 @default.
- W1567106333 hasConcept C203014093 @default.
- W1567106333 hasConcept C2777807096 @default.
- W1567106333 hasConcept C2778004101 @default.
- W1567106333 hasConcept C2780007613 @default.
- W1567106333 hasConcept C2781401929 @default.
- W1567106333 hasConcept C29730261 @default.
- W1567106333 hasConcept C33070731 @default.
- W1567106333 hasConcept C45080847 @default.
- W1567106333 hasConcept C538909803 @default.
- W1567106333 hasConcept C55493867 @default.
- W1567106333 hasConcept C71924100 @default.
- W1567106333 hasConcept C86803240 @default.
- W1567106333 hasConcept C98274493 @default.
- W1567106333 hasConceptScore W1567106333C139066938 @default.
- W1567106333 hasConceptScore W1567106333C178790620 @default.
- W1567106333 hasConceptScore W1567106333C181199279 @default.
- W1567106333 hasConceptScore W1567106333C185592680 @default.
- W1567106333 hasConceptScore W1567106333C203014093 @default.
- W1567106333 hasConceptScore W1567106333C2777807096 @default.
- W1567106333 hasConceptScore W1567106333C2778004101 @default.
- W1567106333 hasConceptScore W1567106333C2780007613 @default.
- W1567106333 hasConceptScore W1567106333C2781401929 @default.
- W1567106333 hasConceptScore W1567106333C29730261 @default.
- W1567106333 hasConceptScore W1567106333C33070731 @default.
- W1567106333 hasConceptScore W1567106333C45080847 @default.
- W1567106333 hasConceptScore W1567106333C538909803 @default.
- W1567106333 hasConceptScore W1567106333C55493867 @default.
- W1567106333 hasConceptScore W1567106333C71924100 @default.
- W1567106333 hasConceptScore W1567106333C86803240 @default.
- W1567106333 hasConceptScore W1567106333C98274493 @default.
- W1567106333 hasIssue "1" @default.
- W1567106333 hasLocation W15671063331 @default.
- W1567106333 hasOpenAccess W1567106333 @default.
- W1567106333 hasPrimaryLocation W15671063331 @default.
- W1567106333 hasRelatedWork W2121771491 @default.
- W1567106333 hasRelatedWork W2348326876 @default.
- W1567106333 hasRelatedWork W2363207273 @default.
- W1567106333 hasRelatedWork W2365267565 @default.
- W1567106333 hasRelatedWork W2380247392 @default.
- W1567106333 hasRelatedWork W2381986359 @default.
- W1567106333 hasRelatedWork W2387874709 @default.
- W1567106333 hasRelatedWork W2391795505 @default.
- W1567106333 hasRelatedWork W2392337094 @default.
- W1567106333 hasRelatedWork W2745924566 @default.
- W1567106333 hasVolume "9" @default.
- W1567106333 isParatext "false" @default.
- W1567106333 isRetracted "false" @default.
- W1567106333 magId "1567106333" @default.
- W1567106333 workType "article" @default.