FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567106898> ?p ?o ?g. }

• W1567106898 endingPage "83" @default.
• W1567106898 startingPage "76" @default.
• W1567106898 abstract "The thick ascending limb of the loop of Henle reabsorbs 20–30% of filtered sodium chloride (NaCl) and generates the osmotic gradient necessary for water absorption in the distal nephron. It is second only to the collecting duct as a source of renal endothelin (ET)-1, which inhibits NaCl reabsorption in the thick ascending limb by reducing NaCl entry into the cell via the furosemide-sensitive Na+/K+/2 Cl– cotransporter. The mechanism by which this occurs appears to be due to activation of ETB receptors, phosphatidylinositol 3 kinase and Akt, and enhanced nitric oxide production by nitric oxide synthase 3. ET-1 may inhibit thick ascending limb NaCl absorption in either an autocrine or paracrine fashion. High-salt intake elevates ET-1 release by thick ascending limbs, although the molecular mechanism involved is unknown. Enhanced ET-1 release and inhibition of thick ascending limb NaCl absorption are thought to be among the mechanisms required to eliminate a salt load without increasing blood pressure. However, we still have much to learn about how ET-1 inhibits thick ascending limb NaCl absorption, how release and processing of ET-1are regulated, and the receptors involved." @default.
• W1567106898 created "2016-06-24" @default.
• W1567106898 creator A5007660267 @default.
• W1567106898 creator A5021025572 @default.
• W1567106898 creator A5067184718 @default.
• W1567106898 date "2011-01-01" @default.
• W1567106898 modified "2023-10-18" @default.
• W1567106898 title "Role of Endothelin in Thick Ascending Limb Sodium Chloride Transport" @default.
• W1567106898 cites W1571495789 @default.
• W1567106898 cites W1763521219 @default.
• W1567106898 cites W1965034540 @default.
• W1567106898 cites W1966895188 @default.
• W1567106898 cites W1983117113 @default.
• W1567106898 cites W1999297702 @default.
• W1567106898 cites W2010706644 @default.
• W1567106898 cites W2035042681 @default.
• W1567106898 cites W2038301155 @default.
• W1567106898 cites W2039512682 @default.
• W1567106898 cites W2039518786 @default.
• W1567106898 cites W2041231522 @default.
• W1567106898 cites W2041376120 @default.
• W1567106898 cites W2044926439 @default.
• W1567106898 cites W2050216269 @default.
• W1567106898 cites W2052237134 @default.
• W1567106898 cites W2071081206 @default.
• W1567106898 cites W2093429155 @default.
• W1567106898 cites W2094988613 @default.
• W1567106898 cites W2116038500 @default.
• W1567106898 cites W2118004990 @default.
• W1567106898 cites W2124001677 @default.
• W1567106898 cites W2136956936 @default.
• W1567106898 cites W2146305131 @default.
• W1567106898 cites W2160616072 @default.
• W1567106898 cites W2168353990 @default.
• W1567106898 cites W2168373342 @default.
• W1567106898 cites W2276899294 @default.
• W1567106898 cites W2282483549 @default.
• W1567106898 cites W2336701702 @default.
• W1567106898 cites W2396896224 @default.
• W1567106898 cites W2401755770 @default.
• W1567106898 cites W2464783535 @default.
• W1567106898 doi "https://doi.org/10.1159/000328686" @default.
• W1567106898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21893990" @default.
• W1567106898 hasPublicationYear "2011" @default.
• W1567106898 type Work @default.
• W1567106898 sameAs 1567106898 @default.
• W1567106898 citedByCount "8" @default.
• W1567106898 countsByYear W15671068982012 @default.
• W1567106898 countsByYear W15671068982015 @default.
• W1567106898 countsByYear W15671068982017 @default.
• W1567106898 countsByYear W15671068982019 @default.
• W1567106898 countsByYear W15671068982020 @default.
• W1567106898 countsByYear W15671068982021 @default.
• W1567106898 countsByYear W15671068982022 @default.
• W1567106898 crossrefType "book-chapter" @default.
• W1567106898 hasAuthorship W1567106898A5007660267 @default.
• W1567106898 hasAuthorship W1567106898A5021025572 @default.
• W1567106898 hasAuthorship W1567106898A5067184718 @default.
• W1567106898 hasConcept C12554922 @default.
• W1567106898 hasConcept C126322002 @default.
• W1567106898 hasConcept C134018914 @default.
• W1567106898 hasConcept C178790620 @default.
• W1567106898 hasConcept C185592680 @default.
• W1567106898 hasConcept C188053792 @default.
• W1567106898 hasConcept C2776844834 @default.
• W1567106898 hasConcept C2778212192 @default.
• W1567106898 hasConcept C2780091579 @default.
• W1567106898 hasConcept C2781231759 @default.
• W1567106898 hasConcept C519581460 @default.
• W1567106898 hasConcept C537181965 @default.
• W1567106898 hasConcept C56906281 @default.
• W1567106898 hasConcept C71924100 @default.
• W1567106898 hasConcept C86803240 @default.
• W1567106898 hasConceptScore W1567106898C12554922 @default.
• W1567106898 hasConceptScore W1567106898C126322002 @default.
• W1567106898 hasConceptScore W1567106898C134018914 @default.
• W1567106898 hasConceptScore W1567106898C178790620 @default.
• W1567106898 hasConceptScore W1567106898C185592680 @default.
• W1567106898 hasConceptScore W1567106898C188053792 @default.
• W1567106898 hasConceptScore W1567106898C2776844834 @default.
• W1567106898 hasConceptScore W1567106898C2778212192 @default.
• W1567106898 hasConceptScore W1567106898C2780091579 @default.
• W1567106898 hasConceptScore W1567106898C2781231759 @default.
• W1567106898 hasConceptScore W1567106898C519581460 @default.
• W1567106898 hasConceptScore W1567106898C537181965 @default.
• W1567106898 hasConceptScore W1567106898C56906281 @default.
• W1567106898 hasConceptScore W1567106898C71924100 @default.
• W1567106898 hasConceptScore W1567106898C86803240 @default.
• W1567106898 hasLocation W15671068981 @default.
• W1567106898 hasLocation W15671068982 @default.
• W1567106898 hasOpenAccess W1567106898 @default.
• W1567106898 hasPrimaryLocation W15671068981 @default.
• W1567106898 hasRelatedWork W1985567618 @default.
• W1567106898 hasRelatedWork W1994850486 @default.
• W1567106898 hasRelatedWork W2005263355 @default.
• W1567106898 hasRelatedWork W2008410862 @default.
• W1567106898 hasRelatedWork W2014673722 @default.
• W1567106898 hasRelatedWork W2045867444 @default.

• next