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- W1567112601 abstract "Malignancy in cancer is associated with aerobic glycolysis (Warburg effect) evidenced by increased trapping of [18F]deoxyglucose (FdG) in patients imaged by positron emission tomography (PET). [18F]deoxyglucose uptake correlates with glucose transporter (GLUT-1) expression, which can be regulated by hypoxia-inducible factor 1 alpha (HIF-1α). We have previously reported in established breast lines that HIF-1α levels in the presence of oxygen leads to the Warburg effect. However, glycolysis and GLUT-1 can also be induced independent of HIF-1α by other factors, such as c-Myc and phosphorylated Akt (pAkt). This study investigates HIF-1α, c-Myc, pAkt, and aerobic glycolysis in low-passage breast cancer cells under the assumption that these represent the in vivo condition better than established lines. Similar to in vivo FdG-PET or primary breast cancers, rates of glycolysis were diverse, being higher in cells expressing both c-Myc and HIF-1α and lower in cell lines low or negative in both transcription factors. No correlations were observed between glycolytic rates and pAkt levels. Two of 12 cell lines formed xenografts in mice. Both were positive for HIF-1α and phosphorylated c-Myc, and only one was positive for pAkt. Glycolysis was affected by pharmacological regulation of c-Myc and HIF-1α. These findings suggest that c-Myc and/or HIF-1α activities are both involved in the regulation of glycolysis in breast cancers." @default.
- W1567112601 created "2016-06-24" @default.
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- W1567112601 date "2008-08-01" @default.
- W1567112601 modified "2023-10-18" @default.
- W1567112601 title "Regulation of the Warburg Effect in Early-Passage Breast Cancer Cells" @default.
- W1567112601 cites W149259628 @default.
- W1567112601 cites W1496795194 @default.
- W1567112601 cites W1518750032 @default.
- W1567112601 cites W1542390137 @default.
- W1567112601 cites W1613477746 @default.
- W1567112601 cites W1726025741 @default.
- W1567112601 cites W1734956365 @default.
- W1567112601 cites W1749022239 @default.
- W1567112601 cites W1758280303 @default.
- W1567112601 cites W1860378841 @default.
- W1567112601 cites W1946385338 @default.
- W1567112601 cites W1970996670 @default.
- W1567112601 cites W1971859682 @default.
- W1567112601 cites W1972640482 @default.
- W1567112601 cites W1976534332 @default.
- W1567112601 cites W1976632546 @default.
- W1567112601 cites W1981929821 @default.
- W1567112601 cites W1987801424 @default.
- W1567112601 cites W1988551940 @default.
- W1567112601 cites W1997757095 @default.
- W1567112601 cites W2002145756 @default.
- W1567112601 cites W2002353048 @default.
- W1567112601 cites W2002752049 @default.
- W1567112601 cites W2010397777 @default.
- W1567112601 cites W2011906546 @default.
- W1567112601 cites W2015408838 @default.
- W1567112601 cites W2019759067 @default.
- W1567112601 cites W2022369905 @default.
- W1567112601 cites W2034822725 @default.
- W1567112601 cites W2036611613 @default.
- W1567112601 cites W2040031153 @default.
- W1567112601 cites W2042325524 @default.
- W1567112601 cites W2042929778 @default.
- W1567112601 cites W2043680485 @default.
- W1567112601 cites W2044190493 @default.
- W1567112601 cites W2045962235 @default.
- W1567112601 cites W2050514368 @default.
- W1567112601 cites W2053213902 @default.
- W1567112601 cites W2057559671 @default.
- W1567112601 cites W2058218780 @default.
- W1567112601 cites W2060628991 @default.
- W1567112601 cites W2066807386 @default.
- W1567112601 cites W2071198735 @default.
- W1567112601 cites W2073292880 @default.
- W1567112601 cites W2078684128 @default.
- W1567112601 cites W2082483448 @default.
- W1567112601 cites W2088715496 @default.
- W1567112601 cites W2091355364 @default.
- W1567112601 cites W2093928399 @default.
- W1567112601 cites W2094165973 @default.
- W1567112601 cites W2098902167 @default.
- W1567112601 cites W2105214585 @default.
- W1567112601 cites W2105477229 @default.
- W1567112601 cites W2106119346 @default.
- W1567112601 cites W2108244474 @default.
- W1567112601 cites W2109421362 @default.
- W1567112601 cites W2112143589 @default.
- W1567112601 cites W2112269002 @default.
- W1567112601 cites W2118611962 @default.
- W1567112601 cites W2121727754 @default.
- W1567112601 cites W2126262617 @default.
- W1567112601 cites W2127652790 @default.
- W1567112601 cites W2129353625 @default.
- W1567112601 cites W2130503287 @default.
- W1567112601 cites W2131518173 @default.
- W1567112601 cites W2134836351 @default.
- W1567112601 cites W2135589093 @default.
- W1567112601 cites W2138033100 @default.
- W1567112601 cites W2139301359 @default.
- W1567112601 cites W2143182501 @default.
- W1567112601 cites W2144625075 @default.
- W1567112601 cites W2150566147 @default.
- W1567112601 cites W2150818243 @default.
- W1567112601 cites W2158428629 @default.
- W1567112601 cites W2159717790 @default.
- W1567112601 cites W2166767348 @default.
- W1567112601 cites W4293162689 @default.
- W1567112601 doi "https://doi.org/10.1593/neo.07724" @default.
- W1567112601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2481565" @default.
- W1567112601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18670636" @default.
- W1567112601 hasPublicationYear "2008" @default.
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