FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567120555> ?p ?o ?g. }

• W1567120555 endingPage "8055" @default.
• W1567120555 startingPage "8048" @default.
• W1567120555 abstract "Human immunodeficiency virus type 2 (HIV-2) causes AIDS, but generally after a much longer asymptomatic period than that which follows infection with HIV-1. At the molecular level, HIV-2 is much more closely related to the simian immunodeficiency viruses than to HIV-1 and our previous studies have demonstrated that HIV-2 and HIV-1 enhancer stimulation is mediated by different sets of cellular proteins following T-cell activation. Similar to HIV-1, HIV-2 encodes a transactivating protein, Tat, which appears to be necessary for viral replication and stimulates viral transcriptional initiation and/or elongation. While Tat-1 binds to the RNA of the trans-activation responsive (TAR) region of HIV-1 and HIV-2, cellular factors that bind to the RNA transcript are also necessary for Tat to function in vivo. Since almost all previous investigations of cellular cofactors for Tat had focused on HIV-1, we undertook studies aimed at understanding the interaction between the TAR RNA region of the HIV-2 promoter (TAR-2) and cellular proteins. By using extension inhibition analysis (toeprinting) and RNA electrophoretic mobility shift assays, we demonstrated binding of a nuclear factor(s) in T cells to the base of the promoter-proximal stem-loop structure. Mutational analysis of this region revealed that both the sequence of the 3' arm and the stem structure itself are important for activation of the promoter by Tat-2. In contrast, the structure is necessary for activation of TAR-2 by Tat-1 but the sequence is less important. These results suggest that a cellular factor interacts with the 3' arm of the proximal stem-loop structure of TAR-2 and mediates Tat-2-induced increases in the level of HIV-2 transcripts." @default.
• W1567120555 created "2016-06-24" @default.
• W1567120555 creator A5007808082 @default.
• W1567120555 creator A5008326144 @default.
• W1567120555 creator A5043907978 @default.
• W1567120555 creator A5057620706 @default.
• W1567120555 creator A5069796670 @default.
• W1567120555 creator A5075367506 @default.
• W1567120555 creator A5081727213 @default.
• W1567120555 date "1997-10-01" @default.
• W1567120555 modified "2023-09-23" @default.
• W1567120555 title "The sequence and structure of the 3' arm of the first stem-loop of the human immunodeficiency virus type 2 trans-activation responsive region mediate Tat-2 transactivation" @default.
• W1567120555 cites W101758419 @default.
• W1567120555 cites W135011339 @default.
• W1567120555 cites W1483097638 @default.
• W1567120555 cites W1489477411 @default.
• W1567120555 cites W1500808920 @default.
• W1567120555 cites W1507020270 @default.
• W1567120555 cites W1527986127 @default.
• W1567120555 cites W1712890974 @default.
• W1567120555 cites W1753280777 @default.
• W1567120555 cites W1830856266 @default.
• W1567120555 cites W1856516975 @default.
• W1567120555 cites W1909475476 @default.
• W1567120555 cites W1948862973 @default.
• W1567120555 cites W1956124594 @default.
• W1567120555 cites W1966425882 @default.
• W1567120555 cites W1976329458 @default.
• W1567120555 cites W1976619298 @default.
• W1567120555 cites W1988399874 @default.
• W1567120555 cites W1990414896 @default.
• W1567120555 cites W1992145903 @default.
• W1567120555 cites W1994291007 @default.
• W1567120555 cites W1998439550 @default.
• W1567120555 cites W2006923455 @default.
• W1567120555 cites W2010050755 @default.
• W1567120555 cites W2010870968 @default.
• W1567120555 cites W2011389067 @default.
• W1567120555 cites W2021906926 @default.
• W1567120555 cites W2031425871 @default.
• W1567120555 cites W2033217413 @default.
• W1567120555 cites W2042884300 @default.
• W1567120555 cites W2044385030 @default.
• W1567120555 cites W2047883045 @default.
• W1567120555 cites W2053572117 @default.
• W1567120555 cites W2060152734 @default.
• W1567120555 cites W2071246036 @default.
• W1567120555 cites W2076941373 @default.
• W1567120555 cites W2077388037 @default.
• W1567120555 cites W2078206395 @default.
• W1567120555 cites W2088493593 @default.
• W1567120555 cites W2089768147 @default.
• W1567120555 cites W2094051732 @default.
• W1567120555 cites W2123864588 @default.
• W1567120555 cites W2124680553 @default.
• W1567120555 cites W2134205683 @default.
• W1567120555 cites W2134935936 @default.
• W1567120555 cites W2139267086 @default.
• W1567120555 cites W2142942720 @default.
• W1567120555 cites W2144206181 @default.
• W1567120555 cites W2165616257 @default.
• W1567120555 cites W2168495771 @default.
• W1567120555 cites W2339056674 @default.
• W1567120555 cites W2407989278 @default.
• W1567120555 cites W2416772658 @default.
• W1567120555 cites W4246358950 @default.
• W1567120555 cites W4250467272 @default.
• W1567120555 cites W46113340 @default.
• W1567120555 doi "https://doi.org/10.1128/jvi.71.10.8048-8055.1997" @default.
• W1567120555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/192170" @default.
• W1567120555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9311903" @default.
• W1567120555 hasPublicationYear "1997" @default.
• W1567120555 type Work @default.
• W1567120555 sameAs 1567120555 @default.
• W1567120555 citedByCount "4" @default.
• W1567120555 crossrefType "journal-article" @default.
• W1567120555 hasAuthorship W1567120555A5007808082 @default.
• W1567120555 hasAuthorship W1567120555A5008326144 @default.
• W1567120555 hasAuthorship W1567120555A5043907978 @default.
• W1567120555 hasAuthorship W1567120555A5057620706 @default.
• W1567120555 hasAuthorship W1567120555A5069796670 @default.
• W1567120555 hasAuthorship W1567120555A5075367506 @default.
• W1567120555 hasAuthorship W1567120555A5081727213 @default.
• W1567120555 hasBestOaLocation W15671205551 @default.
• W1567120555 hasConcept C104317684 @default.
• W1567120555 hasConcept C111936080 @default.
• W1567120555 hasConcept C1292079 @default.
• W1567120555 hasConcept C150194340 @default.
• W1567120555 hasConcept C153911025 @default.
• W1567120555 hasConcept C159047783 @default.
• W1567120555 hasConcept C199491388 @default.
• W1567120555 hasConcept C2910020833 @default.
• W1567120555 hasConcept C54355233 @default.
• W1567120555 hasConcept C67705224 @default.
• W1567120555 hasConcept C86339819 @default.
• W1567120555 hasConcept C86803240 @default.
• W1567120555 hasConcept C95444343 @default.
• W1567120555 hasConceptScore W1567120555C104317684 @default.

• next